Update on Malignancy in Myositis—Well-Established Association with Unmet Needs
Idiopathic inflammatory myopathies are a group of rare connective tissue diseases with a well-documented association with malignancy. The mechanisms underlying the increased risk of neoplasms in the course of myositis are not fully understood. The Pubmed database has been thoroughly screened for art...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/1/111 |
| _version_ | 1797495484391096320 |
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| author | Aleksandra H. Opinc Joanna S. Makowska |
| author_facet | Aleksandra H. Opinc Joanna S. Makowska |
| author_sort | Aleksandra H. Opinc |
| collection | DOAJ |
| description | Idiopathic inflammatory myopathies are a group of rare connective tissue diseases with a well-documented association with malignancy. The mechanisms underlying the increased risk of neoplasms in the course of myositis are not fully understood. The Pubmed database has been thoroughly screened for articles concerning cancer-associated myositis (CAM). The article summarizes the current state of knowledge on the epidemiology and pathogenesis of CAM. Furthermore, it analyses potential risk and protective factors for developing CAM, with particular emphasis on the association with distinct serological profiles. The review summarizes recommendations proposed so far for the management of CAM and presents a novel scheme for cancer screening proposed by the authors. Moreover, promising areas requiring further research were indicated. |
| first_indexed | 2024-03-10T01:50:16Z |
| format | Article |
| id | doaj.art-a87f3ee9a9fd4bca8807f9835f069d5c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:50:16Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a87f3ee9a9fd4bca8807f9835f069d5c2023-11-23T13:07:13ZengMDPI AGBiomolecules2218-273X2022-01-0112111110.3390/biom12010111Update on Malignancy in Myositis—Well-Established Association with Unmet NeedsAleksandra H. Opinc0Joanna S. Makowska1Department of Rheumatology, Medical University of Lodz, Żeromskiego 113, 90-549 Lodz, PolandDepartment of Rheumatology, Medical University of Lodz, Żeromskiego 113, 90-549 Lodz, PolandIdiopathic inflammatory myopathies are a group of rare connective tissue diseases with a well-documented association with malignancy. The mechanisms underlying the increased risk of neoplasms in the course of myositis are not fully understood. The Pubmed database has been thoroughly screened for articles concerning cancer-associated myositis (CAM). The article summarizes the current state of knowledge on the epidemiology and pathogenesis of CAM. Furthermore, it analyses potential risk and protective factors for developing CAM, with particular emphasis on the association with distinct serological profiles. The review summarizes recommendations proposed so far for the management of CAM and presents a novel scheme for cancer screening proposed by the authors. Moreover, promising areas requiring further research were indicated.https://www.mdpi.com/2218-273X/12/1/111cancer-associated myositismyositisidiopathic inflammatory myopathycancerneoplasmmalignancy |
| spellingShingle | Aleksandra H. Opinc Joanna S. Makowska Update on Malignancy in Myositis—Well-Established Association with Unmet Needs Biomolecules cancer-associated myositis myositis idiopathic inflammatory myopathy cancer neoplasm malignancy |
| title | Update on Malignancy in Myositis—Well-Established Association with Unmet Needs |
| title_full | Update on Malignancy in Myositis—Well-Established Association with Unmet Needs |
| title_fullStr | Update on Malignancy in Myositis—Well-Established Association with Unmet Needs |
| title_full_unstemmed | Update on Malignancy in Myositis—Well-Established Association with Unmet Needs |
| title_short | Update on Malignancy in Myositis—Well-Established Association with Unmet Needs |
| title_sort | update on malignancy in myositis well established association with unmet needs |
| topic | cancer-associated myositis myositis idiopathic inflammatory myopathy cancer neoplasm malignancy |
| url | https://www.mdpi.com/2218-273X/12/1/111 |
| work_keys_str_mv | AT aleksandrahopinc updateonmalignancyinmyositiswellestablishedassociationwithunmetneeds AT joannasmakowska updateonmalignancyinmyositiswellestablishedassociationwithunmetneeds |