Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case
Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome has previously been reported in only 2 patients with progressive supranuclear palsy (PSP). Herein, we report a third case of WEBINO syndrome with PSP. The patient was an 81-year-old man who had experienced gradually increasing gait d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2019-07-01
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| Series: | Case Reports in Neurology |
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| Online Access: | https://www.karger.com/Article/FullText/501394 |
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| author | Hideyuki Matsumoto Tatsurou Inaba Toshiyuki Kakumoto Ryoji Miyano Naohiro Uchio Yasuhisa Sakurai |
| author_facet | Hideyuki Matsumoto Tatsurou Inaba Toshiyuki Kakumoto Ryoji Miyano Naohiro Uchio Yasuhisa Sakurai |
| author_sort | Hideyuki Matsumoto |
| collection | DOAJ |
| description | Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome has previously been reported in only 2 patients with progressive supranuclear palsy (PSP). Herein, we report a third case of WEBINO syndrome with PSP. The patient was an 81-year-old man who had experienced gradually increasing gait disturbance and occasional falls since the age of 78 years. At 80 years of age, he presented with cognitive impairment, parkinsonism, and oculomotor abnormalities. The oculomotor abnormalities consisted of vertical gaze palsy and loss of eye convergence. Brain magnetic resonance imaging demonstrated marked atrophy of the midbrain. He was diagnosed with PSP. At the age of 81 years, he presented with alternating extropia in his forward gaze and adduction paresis and outward nystagmus of the abducted eye in his horizontal gaze, both of which were compatible with WEBINO syndrome. Previously, we reported the first case of PSP with WEBINO syndrome, and another group recently reported a second case. In light of the previous cases and the present case, WEBINO syndrome in PSP should not be considered extremely rare. Furthermore, WEBINO syndrome has not been reported in other neurodegenerative disorders, which suggests that it might be a useful and specific diagnostic finding in PSP. |
| first_indexed | 2024-04-12T08:17:54Z |
| format | Article |
| id | doaj.art-a8809246afa243eb9a361b12884a903f |
| institution | Directory Open Access Journal |
| issn | 1662-680X |
| language | English |
| last_indexed | 2024-04-12T08:17:54Z |
| publishDate | 2019-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Neurology |
| spelling | doaj.art-a8809246afa243eb9a361b12884a903f2022-12-22T03:40:43ZengKarger PublishersCase Reports in Neurology1662-680X2019-07-0111220520810.1159/000501394501394Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second CaseHideyuki MatsumotoTatsurou InabaToshiyuki KakumotoRyoji MiyanoNaohiro UchioYasuhisa SakuraiWall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome has previously been reported in only 2 patients with progressive supranuclear palsy (PSP). Herein, we report a third case of WEBINO syndrome with PSP. The patient was an 81-year-old man who had experienced gradually increasing gait disturbance and occasional falls since the age of 78 years. At 80 years of age, he presented with cognitive impairment, parkinsonism, and oculomotor abnormalities. The oculomotor abnormalities consisted of vertical gaze palsy and loss of eye convergence. Brain magnetic resonance imaging demonstrated marked atrophy of the midbrain. He was diagnosed with PSP. At the age of 81 years, he presented with alternating extropia in his forward gaze and adduction paresis and outward nystagmus of the abducted eye in his horizontal gaze, both of which were compatible with WEBINO syndrome. Previously, we reported the first case of PSP with WEBINO syndrome, and another group recently reported a second case. In light of the previous cases and the present case, WEBINO syndrome in PSP should not be considered extremely rare. Furthermore, WEBINO syndrome has not been reported in other neurodegenerative disorders, which suggests that it might be a useful and specific diagnostic finding in PSP.https://www.karger.com/Article/FullText/501394Progressive supranuclear palsyWall-eyed bilateral internuclear ophthalmoplegia syndromeMedial longitudinal fasciculusParamedian pontine reticular formation |
| spellingShingle | Hideyuki Matsumoto Tatsurou Inaba Toshiyuki Kakumoto Ryoji Miyano Naohiro Uchio Yasuhisa Sakurai Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case Case Reports in Neurology Progressive supranuclear palsy Wall-eyed bilateral internuclear ophthalmoplegia syndrome Medial longitudinal fasciculus Paramedian pontine reticular formation |
| title | Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case |
| title_full | Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case |
| title_fullStr | Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case |
| title_full_unstemmed | Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case |
| title_short | Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case |
| title_sort | progressive supranuclear palsy with wall eyed bilateral internuclear ophthalmoplegia syndrome authors second case |
| topic | Progressive supranuclear palsy Wall-eyed bilateral internuclear ophthalmoplegia syndrome Medial longitudinal fasciculus Paramedian pontine reticular formation |
| url | https://www.karger.com/Article/FullText/501394 |
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