Sepsis: emerging role of nitric oxide and selectins
Sepsis-a state of systemic bacterial infection-often leads to multiorgan failure and is associated with high mortality despite the recent advances achieved in intensive care treatment. Many of the ill effects of sepsis are attributed to an abnormally enhanced host inflammatory response that leads to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2006-02-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000100012&tlng=en |
| _version_ | 1818245221485379584 |
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| author | Abhijit Chandra Perenlei Enkhbaatar Yoshimitshu Nakano Lillian D Traber Daniel L. Traber |
| author_facet | Abhijit Chandra Perenlei Enkhbaatar Yoshimitshu Nakano Lillian D Traber Daniel L. Traber |
| author_sort | Abhijit Chandra |
| collection | DOAJ |
| description | Sepsis-a state of systemic bacterial infection-often leads to multiorgan failure and is associated with high mortality despite the recent advances achieved in intensive care treatment. Many of the ill effects of sepsis are attributed to an abnormally enhanced host inflammatory response that leads to neutrophil recruitment and activation involving selectins, a class of adhesion molecules, in the initial stages. Nitric oxide and its various isoforms have also been implicated in various vascular alterations and directly participate in the cellular toxicity in sepsis. This review briefly describes the role of selectins and nitric oxide in experimental and clinical sepsis as well as the therapeutic outcomes of blocking therapies. |
| first_indexed | 2024-12-12T14:29:28Z |
| format | Article |
| id | doaj.art-a8816218736d4516bcb8cf05d0e65639 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T14:29:28Z |
| publishDate | 2006-02-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-a8816218736d4516bcb8cf05d0e656392022-12-22T00:21:35ZengElsevier EspañaClinics1980-53222006-02-01611717610.1590/S1807-59322006000100012Sepsis: emerging role of nitric oxide and selectinsAbhijit Chandra0Perenlei Enkhbaatar1Yoshimitshu Nakano2Lillian D Traber3Daniel L. Traber4King George Medical UniversityUniversity of Texas Medical BranchUniversity of Texas Medical BranchUniversity of Texas Medical BranchUniversity of Texas Medical BranchSepsis-a state of systemic bacterial infection-often leads to multiorgan failure and is associated with high mortality despite the recent advances achieved in intensive care treatment. Many of the ill effects of sepsis are attributed to an abnormally enhanced host inflammatory response that leads to neutrophil recruitment and activation involving selectins, a class of adhesion molecules, in the initial stages. Nitric oxide and its various isoforms have also been implicated in various vascular alterations and directly participate in the cellular toxicity in sepsis. This review briefly describes the role of selectins and nitric oxide in experimental and clinical sepsis as well as the therapeutic outcomes of blocking therapies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000100012&tlng=enSepsisSelectinsNitric oxideMultiorgan failure |
| spellingShingle | Abhijit Chandra Perenlei Enkhbaatar Yoshimitshu Nakano Lillian D Traber Daniel L. Traber Sepsis: emerging role of nitric oxide and selectins Clinics Sepsis Selectins Nitric oxide Multiorgan failure |
| title | Sepsis: emerging role of nitric oxide and selectins |
| title_full | Sepsis: emerging role of nitric oxide and selectins |
| title_fullStr | Sepsis: emerging role of nitric oxide and selectins |
| title_full_unstemmed | Sepsis: emerging role of nitric oxide and selectins |
| title_short | Sepsis: emerging role of nitric oxide and selectins |
| title_sort | sepsis emerging role of nitric oxide and selectins |
| topic | Sepsis Selectins Nitric oxide Multiorgan failure |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000100012&tlng=en |
| work_keys_str_mv | AT abhijitchandra sepsisemergingroleofnitricoxideandselectins AT perenleienkhbaatar sepsisemergingroleofnitricoxideandselectins AT yoshimitshunakano sepsisemergingroleofnitricoxideandselectins AT lilliandtraber sepsisemergingroleofnitricoxideandselectins AT danielltraber sepsisemergingroleofnitricoxideandselectins |