Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings
<i>Background and Objectives</i>: Colorectal cancer (CRC) incidence is rapidly emerging among individuals <50 years, termed as early-onset colorectal cancer (EOCRC). This study aimed to probe variations in tumorigenic pathology and relevant manifestations (polyp and adenoma incidence)...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/11/2017 |
| _version_ | 1797458460237889536 |
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| author | Ilona Vilkoite Ivars Tolmanis Hosams Abu Meri Inese Polaka Linda Mezmale Aivars Lejnieks |
| author_facet | Ilona Vilkoite Ivars Tolmanis Hosams Abu Meri Inese Polaka Linda Mezmale Aivars Lejnieks |
| author_sort | Ilona Vilkoite |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Colorectal cancer (CRC) incidence is rapidly emerging among individuals <50 years, termed as early-onset colorectal cancer (EOCRC). This study aimed to probe variations in tumorigenic pathology and relevant manifestations (polyp and adenoma incidence) between suspected cases of EOCRC and late-onset CRC (LOCRC; ≥50 years of age). <i>Materials and Methods</i>: Between September 2022 and February 2023, colonoscopy-based screening data from 1653 patients were included in this study. All eligible participants were divided into two groups, depending upon patient age, where Group 1 consisted of 1021 patients aged <50 years while Group 2 consisted of 632 patients aged ≥ 50 years. Polyp samples were collected when identified peri-procedurally and characterized according to World Health Organization criteria. <i>Results</i>: Polyp detection rate was 42% for the <50-year age group, while this was 76% for the ≥50-year age group. Additionally, the <50-year age group predominated in hyperplastic polyp manifestation, particularly within the rectum and sigmoid colon. In addition, the ≥50-year age group had increased prevalence of serrated polyps and differing adenoma manifestations. <i>Conclusions</i>: This investigation served to highlight the importance of age stratification for CRC colonoscopy-based screening effectiveness, with particular reference to evaluations that are based on polyp localization within differing colon regions. |
| first_indexed | 2024-03-09T16:37:25Z |
| format | Article |
| id | doaj.art-a881e9bbbbe14ae285cc38e5c8c65039 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T16:37:25Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-a881e9bbbbe14ae285cc38e5c8c650392023-11-24T14:55:03ZengMDPI AGMedicina1010-660X1648-91442023-11-015911201710.3390/medicina59112017Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening FindingsIlona Vilkoite0Ivars Tolmanis1Hosams Abu Meri2Inese Polaka3Linda Mezmale4Aivars Lejnieks5Health Centre 4, LV-1012 Riga, LatviaDigestive Diseases Center GASTRO, LV-1079 Riga, LatviaHealth Centre 4, LV-1012 Riga, LatviaInstitute of Clinical and Preventive Medicine, University of Latvia, LV-1586 Riga, LatviaInstitute of Clinical and Preventive Medicine, University of Latvia, LV-1586 Riga, LatviaDepartment of Internal Diseases, Riga Stradins University, LV-1007 Riga, Latvia<i>Background and Objectives</i>: Colorectal cancer (CRC) incidence is rapidly emerging among individuals <50 years, termed as early-onset colorectal cancer (EOCRC). This study aimed to probe variations in tumorigenic pathology and relevant manifestations (polyp and adenoma incidence) between suspected cases of EOCRC and late-onset CRC (LOCRC; ≥50 years of age). <i>Materials and Methods</i>: Between September 2022 and February 2023, colonoscopy-based screening data from 1653 patients were included in this study. All eligible participants were divided into two groups, depending upon patient age, where Group 1 consisted of 1021 patients aged <50 years while Group 2 consisted of 632 patients aged ≥ 50 years. Polyp samples were collected when identified peri-procedurally and characterized according to World Health Organization criteria. <i>Results</i>: Polyp detection rate was 42% for the <50-year age group, while this was 76% for the ≥50-year age group. Additionally, the <50-year age group predominated in hyperplastic polyp manifestation, particularly within the rectum and sigmoid colon. In addition, the ≥50-year age group had increased prevalence of serrated polyps and differing adenoma manifestations. <i>Conclusions</i>: This investigation served to highlight the importance of age stratification for CRC colonoscopy-based screening effectiveness, with particular reference to evaluations that are based on polyp localization within differing colon regions.https://www.mdpi.com/1648-9144/59/11/2017colorectal cancercolorectal polypcolorectal adenomayoung adultsadenoma detectionearly onset colorectal cancer |
| spellingShingle | Ilona Vilkoite Ivars Tolmanis Hosams Abu Meri Inese Polaka Linda Mezmale Aivars Lejnieks Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings Medicina colorectal cancer colorectal polyp colorectal adenoma young adults adenoma detection early onset colorectal cancer |
| title | Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings |
| title_full | Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings |
| title_fullStr | Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings |
| title_full_unstemmed | Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings |
| title_short | Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings |
| title_sort | age based comparative analysis of colorectal cancer colonoscopy screening findings |
| topic | colorectal cancer colorectal polyp colorectal adenoma young adults adenoma detection early onset colorectal cancer |
| url | https://www.mdpi.com/1648-9144/59/11/2017 |
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