Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus
Abstract Background Diabetes mellitus (DM) often leads to dangerous thromboembolic complications in humans. DM is also a relatively common endocrinopathy of dogs. There is scarce information regarding procoagulant and anticoagulant plasma indicators in this disease. The aim of the study was to evalu...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-022-03179-7 |
| _version_ | 1828854154189078528 |
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| author | Andrzej Milczak Dagmara Winiarczyk Stanisław Winiarczyk Diana Bochyńska Łukasz Adaszek Mateusz Winiarczyk Roman Lechowski |
| author_facet | Andrzej Milczak Dagmara Winiarczyk Stanisław Winiarczyk Diana Bochyńska Łukasz Adaszek Mateusz Winiarczyk Roman Lechowski |
| author_sort | Andrzej Milczak |
| collection | DOAJ |
| description | Abstract Background Diabetes mellitus (DM) often leads to dangerous thromboembolic complications in humans. DM is also a relatively common endocrinopathy of dogs. There is scarce information regarding procoagulant and anticoagulant plasma indicators in this disease. The aim of the study was to evaluate the levels of the selected plasma haemostatic parameters in dogs suffering from diabetes. The study group consisted of 20 dogs meeting all the inclusion criteria, with fasting glycaemia exceeding 11.1 mmol/l. The control group consisted of 15 healthy dogs presented for routine examination. An evaluation of the prothrombin time (PT); and fibrinogen, D-dimer and antithrombin III (ATIII) levels was performed. Results Except for ATIII activity, the haemostatic parameter differences were not statistically significant. High values of ATIII activity were observed in 90% of diabetic dogs. On average, the values amounted to 166.6% and were 31.4% higher than those in the control group. The ATIII activity in the diabetic group was significantly higher than that in the control group (p = 0.0004). Conclusions Here, we report elevated levels of ATIII in diabetic dogs. This finding may suggest the protective role of ATIII against potential thrombotic events. However, the exact role of ATIII in dog diabetes remains unclear. |
| first_indexed | 2024-12-13T00:28:21Z |
| format | Article |
| id | doaj.art-a8822b68d7874a2193047cf2c358e54e |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-13T00:28:21Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-a8822b68d7874a2193047cf2c358e54e2022-12-22T00:05:23ZengBMCBMC Veterinary Research1746-61482022-03-011811710.1186/s12917-022-03179-7Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitusAndrzej Milczak0Dagmara Winiarczyk1Stanisław Winiarczyk2Diana Bochyńska3Łukasz Adaszek4Mateusz Winiarczyk5Roman Lechowski6Department and Clinic of Animal Internal Diseases, Sub-Department of Internal Diseases of Small Animals, University of Life Sciences in LublinDepartment and Clinic of Animal Internal Diseases, Sub-Department of Internal Diseases of Small Animals, University of Life Sciences in LublinDepartment of Epizootiology and Clinic of Infectious Diseases, University of Life Sciences in LublinUniversity of Cambridge, Queen’s Veterinary SchoolDepartment of Epizootiology and Clinic of Infectious Diseases, University of Life Sciences in LublinDepartment of Vitreoretinal Surgery, Medical University of LublinFaculty of Veterinary Medicine, Department of Small Animal Diseases with Clinic, Warsaw University of Life SciencesAbstract Background Diabetes mellitus (DM) often leads to dangerous thromboembolic complications in humans. DM is also a relatively common endocrinopathy of dogs. There is scarce information regarding procoagulant and anticoagulant plasma indicators in this disease. The aim of the study was to evaluate the levels of the selected plasma haemostatic parameters in dogs suffering from diabetes. The study group consisted of 20 dogs meeting all the inclusion criteria, with fasting glycaemia exceeding 11.1 mmol/l. The control group consisted of 15 healthy dogs presented for routine examination. An evaluation of the prothrombin time (PT); and fibrinogen, D-dimer and antithrombin III (ATIII) levels was performed. Results Except for ATIII activity, the haemostatic parameter differences were not statistically significant. High values of ATIII activity were observed in 90% of diabetic dogs. On average, the values amounted to 166.6% and were 31.4% higher than those in the control group. The ATIII activity in the diabetic group was significantly higher than that in the control group (p = 0.0004). Conclusions Here, we report elevated levels of ATIII in diabetic dogs. This finding may suggest the protective role of ATIII against potential thrombotic events. However, the exact role of ATIII in dog diabetes remains unclear.https://doi.org/10.1186/s12917-022-03179-7Antithrombin IIICanine diabetesDiabetesThrombosisBlood coagulation |
| spellingShingle | Andrzej Milczak Dagmara Winiarczyk Stanisław Winiarczyk Diana Bochyńska Łukasz Adaszek Mateusz Winiarczyk Roman Lechowski Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus BMC Veterinary Research Antithrombin III Canine diabetes Diabetes Thrombosis Blood coagulation |
| title | Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus |
| title_full | Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus |
| title_fullStr | Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus |
| title_full_unstemmed | Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus |
| title_short | Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus |
| title_sort | procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin iii levels in canine diabetes mellitus |
| topic | Antithrombin III Canine diabetes Diabetes Thrombosis Blood coagulation |
| url | https://doi.org/10.1186/s12917-022-03179-7 |
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