Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes

Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes

Lymph-node metastasis is a prognosis factor for poor clinical outcome of breast cancer patients. Currently, how breast cancer cells establish pre-metastatic niche in the tumor-draining lymph nodes (TDLNs) is still unclear. To address this question, we isolated heterogeneous cells including immune an...

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Bibliographic Details
Main Authors: Yen-Liang Li, Chung-Hsing Chen, Jing-Yi Chen, You-Syuan Lai, Shao-Chun Wang, Shih-Sheng Jiang, Wen-Chun Hung
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
single-cell rna sequencing
tumor-draining lymph node
fibroblastic reticular cells
mmtv-pymt mice
oxidative phosphorylation
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1830513

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