Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
(1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7265 |
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| author | Chin-Yu Lin Fa-Po Chung Nwe Nwe Yu-Cheng Hsieh Cheng-Hung Li Yenn-Jiang Lin Shih-Lin Chang Li-Wei Lo Yu-Feng Hu Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Ting-Yung Chang Ling Kuo Cheng-I Wu Chih-Min Liu Shin-Huei Liu Wen-Han Cheng Shih-Ann Chen |
| author_facet | Chin-Yu Lin Fa-Po Chung Nwe Nwe Yu-Cheng Hsieh Cheng-Hung Li Yenn-Jiang Lin Shih-Lin Chang Li-Wei Lo Yu-Feng Hu Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Ting-Yung Chang Ling Kuo Cheng-I Wu Chih-Min Liu Shin-Huei Liu Wen-Han Cheng Shih-Ann Chen |
| author_sort | Chin-Yu Lin |
| collection | DOAJ |
| description | (1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT. In all patients, substrate modification was performed to achieve non-inducible VT. The patients were categorized into two groups according to whether they had used amiodarone before CA. Baseline and electrophysiological characteristics, substrate, and outcomes were compared. (3) Results: A total of 72 ARVC patients were studied, including 29 (40.3%) “off” amiodarone and 43 (56.7%) “on” amiodarone. The scar area was similar between the two groups. Patients “off” amiodarone had smaller endocardial and epicardial areas with abnormal electrograms. Twenty of 43 patients (47.5%) “on” amiodarone discontinued it within 3 months after CA. During a mean follow-up period of 43.2 ± 29.5 months, higher VT recurrence was observed in patients “on” amiodarone. Patients “on” amiodarone who discontinued amiodarone after CA had a lower recurrence than those without. (4) Conclusions: Patients with ARVC “on” amiodarone before CA had distinct substrate characteristics and worse ablation outcomes than patients “off” amiodarone, especially in those who had used amiodarone continuously. |
| first_indexed | 2024-03-09T16:17:02Z |
| format | Article |
| id | doaj.art-a8844cc6ae534443a3601f5cd0c0c77a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:17:02Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a8844cc6ae534443a3601f5cd0c0c77a2023-11-24T15:42:33ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124726510.3390/jcm11247265Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular CardiomyopathyChin-Yu Lin0Fa-Po Chung1Nwe Nwe2Yu-Cheng Hsieh3Cheng-Hung Li4Yenn-Jiang Lin5Shih-Lin Chang6Li-Wei Lo7Yu-Feng Hu8Ta-Chuan Tuan9Tze-Fan Chao10Jo-Nan Liao11Ting-Yung Chang12Ling Kuo13Cheng-I Wu14Chih-Min Liu15Shin-Huei Liu16Wen-Han Cheng17Shih-Ann Chen18Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanDepartment of Cardiology, Yangon General Hospital, Yangon Q4HX+MH5, MyanmarDepartment of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, TaiwanDepartment of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, TaiwanDepartment of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan(1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT. In all patients, substrate modification was performed to achieve non-inducible VT. The patients were categorized into two groups according to whether they had used amiodarone before CA. Baseline and electrophysiological characteristics, substrate, and outcomes were compared. (3) Results: A total of 72 ARVC patients were studied, including 29 (40.3%) “off” amiodarone and 43 (56.7%) “on” amiodarone. The scar area was similar between the two groups. Patients “off” amiodarone had smaller endocardial and epicardial areas with abnormal electrograms. Twenty of 43 patients (47.5%) “on” amiodarone discontinued it within 3 months after CA. During a mean follow-up period of 43.2 ± 29.5 months, higher VT recurrence was observed in patients “on” amiodarone. Patients “on” amiodarone who discontinued amiodarone after CA had a lower recurrence than those without. (4) Conclusions: Patients with ARVC “on” amiodarone before CA had distinct substrate characteristics and worse ablation outcomes than patients “off” amiodarone, especially in those who had used amiodarone continuously.https://www.mdpi.com/2077-0383/11/24/7265amiodaronearrhythmogenic right ventricular cardiomyopathyabnormal electrogramsventricular tachycardiaablation |
| spellingShingle | Chin-Yu Lin Fa-Po Chung Nwe Nwe Yu-Cheng Hsieh Cheng-Hung Li Yenn-Jiang Lin Shih-Lin Chang Li-Wei Lo Yu-Feng Hu Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Ting-Yung Chang Ling Kuo Cheng-I Wu Chih-Min Liu Shin-Huei Liu Wen-Han Cheng Shih-Ann Chen Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy Journal of Clinical Medicine amiodarone arrhythmogenic right ventricular cardiomyopathy abnormal electrograms ventricular tachycardia ablation |
| title | Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy |
| title_full | Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy |
| title_fullStr | Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy |
| title_full_unstemmed | Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy |
| title_short | Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy |
| title_sort | impact of amiodarone therapy on the ablation outcome of ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy |
| topic | amiodarone arrhythmogenic right ventricular cardiomyopathy abnormal electrograms ventricular tachycardia ablation |
| url | https://www.mdpi.com/2077-0383/11/24/7265 |
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