Design and characterization of a SYBR Green I-based melting curve method for investigation of HER2I655V polymorphism in breast cancer

Design and characterization of a SYBR Green I-based melting curve method for investigation of HER2I655V polymorphism in breast cancer

Abstract Background Breast cancer is a disease in which cell grows rapidly forming a mass in the breast. HER2 polymorphisms Ile655Val have been studied as biomarkers for breast cancer and may comprise a risk factor of cardiac toxicity for breast cancer-consuming trastuzumab. Aim of work: In this stu...

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Bibliographic Details
Main Authors: Desriani, Azamris, Shabrina S. Ghaissani, Senja R. Kinanti, Muhammad A. Warisman, N. Fitria
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Tm Shift SYBR Green I
qPCR assay
HER-2 Ile655Val Detection
Breast cancer
Trastuzumab
Online Access:https://doi.org/10.1186/s43141-020-00108-9

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