Agomelatine protects against neuronal damage without preventing epileptogenesis in the kainate model of temporal lobe epilepsy

Agomelatine protects against neuronal damage without preventing epileptogenesis in the kainate model of temporal lobe epilepsy

Recent studies about the novel antidepressant agomelatine, which is a mixed MT1 and MT2 melatonin receptor agonist and 5HT2C serotonin receptor antagonist possessing an anticonvulsant and neuroprotective action, suggest that it may have potential to contribute against epileptogenesis and epilepsy-in...

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Bibliographic Details
Main Authors: Jana Tchekalarova, Dimitrinka Atanasova, Zlatina Nenchovska, Milena Atanasova, Lidia Kortenska, Rumyana Gesheva, Nikolai Lazarov
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Neurobiology of Disease
Subjects:
Agomelatine
Kainate
Epileptogenesis
Behavior
Neuronal loss
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300918

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