Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis.
BACKGROUND:Oxidative stress is a key player in the genesis and worsening of diabetic kidney disease (DKD). We aimed at collecting all available information on possible benefits of chronic antioxidant supplementations on DKD progression. STUDY DESIGN:Systematic review and meta-analysis. POPULATION:Ad...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5453586?pdf=render |
| _version_ | 1818237989922275328 |
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| author | Davide Bolignano Valeria Cernaro Guido Gembillo Rossella Baggetta Michele Buemi Graziella D'Arrigo |
| author_facet | Davide Bolignano Valeria Cernaro Guido Gembillo Rossella Baggetta Michele Buemi Graziella D'Arrigo |
| author_sort | Davide Bolignano |
| collection | DOAJ |
| description | BACKGROUND:Oxidative stress is a key player in the genesis and worsening of diabetic kidney disease (DKD). We aimed at collecting all available information on possible benefits of chronic antioxidant supplementations on DKD progression. STUDY DESIGN:Systematic review and meta-analysis. POPULATION:Adults with DKD (either secondary to type 1 or 2 diabetes mellitus). SEARCH STRATEGY AND SOURCES:Cochrane CENTRAL, Ovid-MEDLINE and PubMed were searched for randomized controlled trials (RCTs) or quasi-RCTs without language or follow-up restriction. INTERVENTION:Any antioxidant supplementation (including but not limited to vitamin A, vitamin C, vitamin E, selenium, zinc, methionine or ubiquinone) alone or in combination. OUTCOMES:Primary outcome was progression to end-stage kidney disease (ESKD). Secondary outcomes were change in albuminuria, proteinuria, serum creatinine and renal function. RESULTS:From 13519 potentially relevant citations retrieved, 15 articles referring to 14 full studies (4345 participants) met the inclusion criteria. Antioxidant treatment significantly decreased albuminuria as compared to control (8 studies, 327 participants; SMD: -0.47; 95% CI -0.78, -0.16) but had apparently no tangible effects on renal function (GFR) (3 studies, 85 participants; MD -0.12 ml/min/1.73m2; 95% CI -0.06, 0.01). Evidence of benefits on the other outcomes of interest was inconclusive or lacking. LIMITATIONS:Small sample size and limited number of studies. Scarce information available on hard endpoints (ESKD). High heterogeneity among studies with respect to DKD severity, type and duration of antioxidant therapy. CONCLUSIONS:In DKD patients, antioxidants may improve early renal damage. Future studies targeting hard endpoints and with longer follow-up and larger sample size are needed to confirm the usefulness of these agents for retarding DKD progression. |
| first_indexed | 2024-12-12T12:34:32Z |
| format | Article |
| id | doaj.art-a88d1ddd7682473593ad16a03bea6511 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T12:34:32Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a88d1ddd7682473593ad16a03bea65112022-12-22T00:24:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017869910.1371/journal.pone.0178699Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis.Davide BolignanoValeria CernaroGuido GembilloRossella BaggettaMichele BuemiGraziella D'ArrigoBACKGROUND:Oxidative stress is a key player in the genesis and worsening of diabetic kidney disease (DKD). We aimed at collecting all available information on possible benefits of chronic antioxidant supplementations on DKD progression. STUDY DESIGN:Systematic review and meta-analysis. POPULATION:Adults with DKD (either secondary to type 1 or 2 diabetes mellitus). SEARCH STRATEGY AND SOURCES:Cochrane CENTRAL, Ovid-MEDLINE and PubMed were searched for randomized controlled trials (RCTs) or quasi-RCTs without language or follow-up restriction. INTERVENTION:Any antioxidant supplementation (including but not limited to vitamin A, vitamin C, vitamin E, selenium, zinc, methionine or ubiquinone) alone or in combination. OUTCOMES:Primary outcome was progression to end-stage kidney disease (ESKD). Secondary outcomes were change in albuminuria, proteinuria, serum creatinine and renal function. RESULTS:From 13519 potentially relevant citations retrieved, 15 articles referring to 14 full studies (4345 participants) met the inclusion criteria. Antioxidant treatment significantly decreased albuminuria as compared to control (8 studies, 327 participants; SMD: -0.47; 95% CI -0.78, -0.16) but had apparently no tangible effects on renal function (GFR) (3 studies, 85 participants; MD -0.12 ml/min/1.73m2; 95% CI -0.06, 0.01). Evidence of benefits on the other outcomes of interest was inconclusive or lacking. LIMITATIONS:Small sample size and limited number of studies. Scarce information available on hard endpoints (ESKD). High heterogeneity among studies with respect to DKD severity, type and duration of antioxidant therapy. CONCLUSIONS:In DKD patients, antioxidants may improve early renal damage. Future studies targeting hard endpoints and with longer follow-up and larger sample size are needed to confirm the usefulness of these agents for retarding DKD progression.http://europepmc.org/articles/PMC5453586?pdf=render |
| spellingShingle | Davide Bolignano Valeria Cernaro Guido Gembillo Rossella Baggetta Michele Buemi Graziella D'Arrigo Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis. PLoS ONE |
| title | Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis. |
| title_full | Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis. |
| title_fullStr | Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis. |
| title_full_unstemmed | Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis. |
| title_short | Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis. |
| title_sort | antioxidant agents for delaying diabetic kidney disease progression a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC5453586?pdf=render |
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