The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells
To maintain a range of cellular functions and to ensure cell survival, cells must control their levels of reactive oxygen species (ROS). The main source of these molecules is the mitochondrial respiration machinery, and the first line of defense against these toxic substances is the mitochondrial en...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1250643/full |
| _version_ | 1827782609930813440 |
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| author | Katsiaryna Tarbashevich Laura Ermlich Julian Wegner Jana Pfeiffer Erez Raz Erez Raz |
| author_facet | Katsiaryna Tarbashevich Laura Ermlich Julian Wegner Jana Pfeiffer Erez Raz Erez Raz |
| author_sort | Katsiaryna Tarbashevich |
| collection | DOAJ |
| description | To maintain a range of cellular functions and to ensure cell survival, cells must control their levels of reactive oxygen species (ROS). The main source of these molecules is the mitochondrial respiration machinery, and the first line of defense against these toxic substances is the mitochondrial enzyme superoxide dismutase 2 (Sod2). Thus, investigating early expression patterns and functions of this protein is critical for understanding how an organism develops ways to protect itself against ROS and enhance tissue fitness. Here, we report on expression pattern and function of zebrafish Sod2, focusing on the role of the protein in migration and maintenance of primordial germ cells during early embryonic development. We provide evidence that Sod2 is involved in purifying selection of vertebrate germ cells, which can contribute to the fitness of the organism in the following generations. |
| first_indexed | 2024-03-11T15:35:20Z |
| format | Article |
| id | doaj.art-a88f63869e464d9f96c4dcf70eca49ef |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T15:35:20Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a88f63869e464d9f96c4dcf70eca49ef2023-10-26T22:37:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-10-011110.3389/fcell.2023.12506431250643The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cellsKatsiaryna Tarbashevich0Laura Ermlich1Julian Wegner2Jana Pfeiffer3Erez Raz4Erez Raz5Institute of Cell Biology, Center for Molecular Biology of Inflammation (ZMBE), Muenster, GermanyInstitute of Cell Biology, Center for Molecular Biology of Inflammation (ZMBE), Muenster, GermanyInstitute of Cell Biology, Center for Molecular Biology of Inflammation (ZMBE), Muenster, GermanyInstitute of Cell Biology, Center for Molecular Biology of Inflammation (ZMBE), Muenster, GermanyInstitute of Cell Biology, Center for Molecular Biology of Inflammation (ZMBE), Muenster, GermanyMax Planck Institute for Molecular Biomedicine, Münster, GermanyTo maintain a range of cellular functions and to ensure cell survival, cells must control their levels of reactive oxygen species (ROS). The main source of these molecules is the mitochondrial respiration machinery, and the first line of defense against these toxic substances is the mitochondrial enzyme superoxide dismutase 2 (Sod2). Thus, investigating early expression patterns and functions of this protein is critical for understanding how an organism develops ways to protect itself against ROS and enhance tissue fitness. Here, we report on expression pattern and function of zebrafish Sod2, focusing on the role of the protein in migration and maintenance of primordial germ cells during early embryonic development. We provide evidence that Sod2 is involved in purifying selection of vertebrate germ cells, which can contribute to the fitness of the organism in the following generations.https://www.frontiersin.org/articles/10.3389/fcell.2023.1250643/fullSOD2mitochondriagerm cellszebrafishcell competitioncell migration |
| spellingShingle | Katsiaryna Tarbashevich Laura Ermlich Julian Wegner Jana Pfeiffer Erez Raz Erez Raz The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells Frontiers in Cell and Developmental Biology SOD2 mitochondria germ cells zebrafish cell competition cell migration |
| title | The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells |
| title_full | The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells |
| title_fullStr | The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells |
| title_full_unstemmed | The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells |
| title_short | The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells |
| title_sort | mitochondrial protein sod2 is important for the migration maintenance and fitness of germ cells |
| topic | SOD2 mitochondria germ cells zebrafish cell competition cell migration |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1250643/full |
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