Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control
Background: Management of pain and discomfort is important to make the postoperative period as pleasant as possible. Nonsteroidal anti-inflammatory drugs are traditionally prescribed; however, they are associated with numerous side effects. As a result, nutraceuticals such as curcumin are widely use...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | http://www.jisponline.com/article.asp?issn=0972-124X;year=2019;volume=23;issue=5;spage=461;epage=468;aulast=Anil |
| _version_ | 1818539960931713024 |
|---|---|
| author | Anu Anil Sheela Kumar Gujjari Madhugiri Prakash Venkatesh |
| author_facet | Anu Anil Sheela Kumar Gujjari Madhugiri Prakash Venkatesh |
| author_sort | Anu Anil |
| collection | DOAJ |
| description | Background: Management of pain and discomfort is important to make the postoperative period as pleasant as possible. Nonsteroidal anti-inflammatory drugs are traditionally prescribed; however, they are associated with numerous side effects. As a result, nutraceuticals such as curcumin are widely used for its well-known safety and medicinal values. Hence, the aim of this study is to evaluate the efficacy of a curcumin mucoadhesive film for postsurgical pain control. Materials and Methods: This was a split-mouth study, consisting of 15 systemically healthy patients with 30 sites, who were randomly allocated into test (curcumin mucoadhesive film) and control (placebo mucoadhesive film) groups using coin toss method. A questionnaire was given to patients to evaluate the postoperative pain and swelling and the number of rescue medications taken. Statistical analyses used were Friedman test, Wilcoxon signed-rank test, and McNemar's test. Results: No adverse effects were reported and healing was uneventful in all patients. The Numerical rating scale pain score showed significantly lesser pain at 1, 2, 3, 4, 5, and 24 h in the test group. Significantly more number of analgesics was consumed in total in the control group than that in the test group. Conclusion: Within the limitations of this study, it may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries. |
| first_indexed | 2024-12-11T21:49:03Z |
| format | Article |
| id | doaj.art-a89164a0146147bcab1f4568ac349d0b |
| institution | Directory Open Access Journal |
| issn | 0972-124X |
| language | English |
| last_indexed | 2024-12-11T21:49:03Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj.art-a89164a0146147bcab1f4568ac349d0b2022-12-22T00:49:32ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X2019-01-0123546146810.4103/jisp.jisp_700_18Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain controlAnu AnilSheela Kumar GujjariMadhugiri Prakash VenkateshBackground: Management of pain and discomfort is important to make the postoperative period as pleasant as possible. Nonsteroidal anti-inflammatory drugs are traditionally prescribed; however, they are associated with numerous side effects. As a result, nutraceuticals such as curcumin are widely used for its well-known safety and medicinal values. Hence, the aim of this study is to evaluate the efficacy of a curcumin mucoadhesive film for postsurgical pain control. Materials and Methods: This was a split-mouth study, consisting of 15 systemically healthy patients with 30 sites, who were randomly allocated into test (curcumin mucoadhesive film) and control (placebo mucoadhesive film) groups using coin toss method. A questionnaire was given to patients to evaluate the postoperative pain and swelling and the number of rescue medications taken. Statistical analyses used were Friedman test, Wilcoxon signed-rank test, and McNemar's test. Results: No adverse effects were reported and healing was uneventful in all patients. The Numerical rating scale pain score showed significantly lesser pain at 1, 2, 3, 4, 5, and 24 h in the test group. Significantly more number of analgesics was consumed in total in the control group than that in the test group. Conclusion: Within the limitations of this study, it may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries.http://www.jisponline.com/article.asp?issn=0972-124X;year=2019;volume=23;issue=5;spage=461;epage=468;aulast=AnilAnalgesicanti-inflammatorychronic periodontitiscurcuminmucoadhesive filmnumerical rating scalepain assessmentpostoperative painswelling |
| spellingShingle | Anu Anil Sheela Kumar Gujjari Madhugiri Prakash Venkatesh Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control Journal of Indian Society of Periodontology Analgesic anti-inflammatory chronic periodontitis curcumin mucoadhesive film numerical rating scale pain assessment postoperative pain swelling |
| title | Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control |
| title_full | Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control |
| title_fullStr | Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control |
| title_full_unstemmed | Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control |
| title_short | Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control |
| title_sort | evaluation of a curcumin containing mucoadhesive film for periodontal postsurgical pain control |
| topic | Analgesic anti-inflammatory chronic periodontitis curcumin mucoadhesive film numerical rating scale pain assessment postoperative pain swelling |
| url | http://www.jisponline.com/article.asp?issn=0972-124X;year=2019;volume=23;issue=5;spage=461;epage=468;aulast=Anil |
| work_keys_str_mv | AT anuanil evaluationofacurcumincontainingmucoadhesivefilmforperiodontalpostsurgicalpaincontrol AT sheelakumargujjari evaluationofacurcumincontainingmucoadhesivefilmforperiodontalpostsurgicalpaincontrol AT madhugiriprakashvenkatesh evaluationofacurcumincontainingmucoadhesivefilmforperiodontalpostsurgicalpaincontrol |