COMPARATIVE ANALYSIS OF THE FREQUENCY AND STRUCTURE OF COMPLICATIONS OF THE BCG AND BCG-M TUBERCULOSIS VACCINE
Introduction. The effectiveness of TB vaccination is low in more than half of children with tuberculosis, which is confirmed by the small size of the post-vaccination scar or its absence. Having a residual virulence, the BCG strain can cause the development of post-vaccination complications. Object...
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| Formáid: | Alt |
| Teanga: | Belarusian |
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Grodno State Medical University
2021-03-01
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| Sraith: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
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| Rochtain ar líne: | http://journal-grsmu.by/index.php/ojs/article/view/2438/2213 |
| Achoimre: | Introduction. The effectiveness of TB vaccination is low in more than half of children with tuberculosis, which is confirmed by the small size of the post-vaccination scar or its absence. Having a residual virulence, the BCG strain can cause the development of post-vaccination complications.
Objective – to conduct a comparative analysis of the frequency and structure of complications of TB vaccination with BCG and BCG-M in children.
Material and methods. The analysis of the frequency and structure of complications was carried out in 284 children in BCG vaccination, in 273 children in BCG-M vaccine.
Results. The use of BCG-M vaccine reduced the frequency and proportion of complications, and improved the structure of post-vaccination complications. The development of complications is associated with altered immunological reactivity of the child, which is manifested by a decrease in the activation potential of T-lymphocytes and functional insufficiency of humoral immune cells.
Conclusions. During the period of TB vaccination, a thorough clinical and laboratory analysis of children with perinatal pathology is necessary to exclude immune insufficiency and reduce the risk of complications. |
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| ISSN: | 2221-8785 2413-0109 |