Intestinal Microbes in Autoimmune and Inflammatory Disease
Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflamm...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.597966/full |
| _version_ | 1831541594768015360 |
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| author | Wan-Jung H. Wu Wan-Jung H. Wu Daniel F. Zegarra-Ruiz Gretchen E. Diehl |
| author_facet | Wan-Jung H. Wu Wan-Jung H. Wu Daniel F. Zegarra-Ruiz Gretchen E. Diehl |
| author_sort | Wan-Jung H. Wu |
| collection | DOAJ |
| description | Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflammation and pathology. Current evidence supports the microbiota as one such factor with emerging data linking commensal organisms to the onset and progression of disease. In this review, we will discuss links between the microbiota and specific diseases as well as highlight common pathways that link intestinal microbes with multiple autoimmune and inflammatory diseases. |
| first_indexed | 2024-12-17T00:20:14Z |
| format | Article |
| id | doaj.art-a894412908a44bf2b4e48a9ccd4a53e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T00:20:14Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a894412908a44bf2b4e48a9ccd4a53e02022-12-21T22:10:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-12-011110.3389/fimmu.2020.597966597966Intestinal Microbes in Autoimmune and Inflammatory DiseaseWan-Jung H. Wu0Wan-Jung H. Wu1Daniel F. Zegarra-Ruiz2Gretchen E. Diehl3Immunology Graduate Program, Baylor College of Medicine, Houston, TX, United StatesImmunology Program of the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesImmunology Program of the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesImmunology Program of the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesAutoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflammation and pathology. Current evidence supports the microbiota as one such factor with emerging data linking commensal organisms to the onset and progression of disease. In this review, we will discuss links between the microbiota and specific diseases as well as highlight common pathways that link intestinal microbes with multiple autoimmune and inflammatory diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2020.597966/fullmultiple sclerosisautoimmunityinflammationinflammatory bowel diseasetype 1 diabetesrheumathoid arthritis |
| spellingShingle | Wan-Jung H. Wu Wan-Jung H. Wu Daniel F. Zegarra-Ruiz Gretchen E. Diehl Intestinal Microbes in Autoimmune and Inflammatory Disease Frontiers in Immunology multiple sclerosis autoimmunity inflammation inflammatory bowel disease type 1 diabetes rheumathoid arthritis |
| title | Intestinal Microbes in Autoimmune and Inflammatory Disease |
| title_full | Intestinal Microbes in Autoimmune and Inflammatory Disease |
| title_fullStr | Intestinal Microbes in Autoimmune and Inflammatory Disease |
| title_full_unstemmed | Intestinal Microbes in Autoimmune and Inflammatory Disease |
| title_short | Intestinal Microbes in Autoimmune and Inflammatory Disease |
| title_sort | intestinal microbes in autoimmune and inflammatory disease |
| topic | multiple sclerosis autoimmunity inflammation inflammatory bowel disease type 1 diabetes rheumathoid arthritis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.597966/full |
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