Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer
Lung cancer is the leading cause of deaths resulting from cancer owing to late diagnosis and limited treatment intervention. MicroRNAs are short, non-coding RNA molecules that regulate gene expression post-transcriptionally by translational repression or target messenger RNA degradation. Accumulatin...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-05-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/9/5/49 |
| _version_ | 1797726590132551680 |
|---|---|
| author | Kentaro Inamura |
| author_facet | Kentaro Inamura |
| author_sort | Kentaro Inamura |
| collection | DOAJ |
| description | Lung cancer is the leading cause of deaths resulting from cancer owing to late diagnosis and limited treatment intervention. MicroRNAs are short, non-coding RNA molecules that regulate gene expression post-transcriptionally by translational repression or target messenger RNA degradation. Accumulating evidence suggests various roles for microRNAs, including development and progression of lung cancers. Because microRNAs are degraded to a much lesser extent in formalin-fixed paraffin-embedded specimens and are present not only in tumor tissues but also in body fluids, there is an increased potential in microRNA analyses for cancer research. In this review, recent studies of microRNA are introduced and briefly summarized, with a focus on the association of microRNAs with histological subtypes, genetic driver alterations, therapeutically-targeted molecules, and carcinogens. The reported circulating microRNA signature for the early detection of lung cancer and the implications of microRNAs as the modulators of tumor immune response are also introduced. |
| first_indexed | 2024-03-12T10:47:49Z |
| format | Article |
| id | doaj.art-a89471015b4e4b71bbc0a2e3b4b1ed5e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:47:49Z |
| publishDate | 2017-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a89471015b4e4b71bbc0a2e3b4b1ed5e2023-09-02T07:20:59ZengMDPI AGCancers2072-66942017-05-01954910.3390/cancers9050049cancers9050049Diagnostic and Therapeutic Potential of MicroRNAs in Lung CancerKentaro Inamura0Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, JapanLung cancer is the leading cause of deaths resulting from cancer owing to late diagnosis and limited treatment intervention. MicroRNAs are short, non-coding RNA molecules that regulate gene expression post-transcriptionally by translational repression or target messenger RNA degradation. Accumulating evidence suggests various roles for microRNAs, including development and progression of lung cancers. Because microRNAs are degraded to a much lesser extent in formalin-fixed paraffin-embedded specimens and are present not only in tumor tissues but also in body fluids, there is an increased potential in microRNA analyses for cancer research. In this review, recent studies of microRNA are introduced and briefly summarized, with a focus on the association of microRNAs with histological subtypes, genetic driver alterations, therapeutically-targeted molecules, and carcinogens. The reported circulating microRNA signature for the early detection of lung cancer and the implications of microRNAs as the modulators of tumor immune response are also introduced.http://www.mdpi.com/2072-6694/9/5/49adenocarcinomaasbestosdriver mutationgenetic alterationhistologymiRNAmolecular pathologyoncologysmoking |
| spellingShingle | Kentaro Inamura Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer Cancers adenocarcinoma asbestos driver mutation genetic alteration histology miRNA molecular pathology oncology smoking |
| title | Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer |
| title_full | Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer |
| title_fullStr | Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer |
| title_full_unstemmed | Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer |
| title_short | Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer |
| title_sort | diagnostic and therapeutic potential of micrornas in lung cancer |
| topic | adenocarcinoma asbestos driver mutation genetic alteration histology miRNA molecular pathology oncology smoking |
| url | http://www.mdpi.com/2072-6694/9/5/49 |
| work_keys_str_mv | AT kentaroinamura diagnosticandtherapeuticpotentialofmicrornasinlungcancer |