Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea
Aims: Obstructive sleep apnea (OSA) and insomnia commonly coexist; hypnotics are broadly prescribed for insomnia therapy. However, the safety of hypnotics use in OSA patients is unclear. We conducted a retrospective case-control study to investigate the risk of adverse respiratory events in hypnotic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01513/full |
| _version_ | 1819120828938190848 |
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| author | Sheng-Huei Wang Wei-Shan Chen Wei-Shan Chen Shih-En Tang Hung-Che Lin Hung-Che Lin Chung-Kan Peng Hsuan-Te Chu Chia-Hung Kao Chia-Hung Kao Chia-Hung Kao |
| author_facet | Sheng-Huei Wang Wei-Shan Chen Wei-Shan Chen Shih-En Tang Hung-Che Lin Hung-Che Lin Chung-Kan Peng Hsuan-Te Chu Chia-Hung Kao Chia-Hung Kao Chia-Hung Kao |
| author_sort | Sheng-Huei Wang |
| collection | DOAJ |
| description | Aims: Obstructive sleep apnea (OSA) and insomnia commonly coexist; hypnotics are broadly prescribed for insomnia therapy. However, the safety of hypnotics use in OSA patients is unclear. We conducted a retrospective case-control study to investigate the risk of adverse respiratory events in hypnotics-using OSA patients.Methods: We obtained data from the Taiwan National Health Insurance Database from 1996 to 2013. The case group included 216 OSA patients with newly diagnosed adverse respiratory events, including pneumonia and acute respiratory failure. The control group included OSA patients without adverse respiratory events, which was randomly frequency-matched to the case group at a 1:1 ratio according to age, gender, and index year. Hypnotics exposure included benzodiazepines (BZD) and non-benzodiazepines (non-BZD). A recent user was defined as a patient who had taken hypnotics for 1–30 days, while a long-term user was one who had taken hypnotics for 31–365 days.Results: Multivariable adjusted analysis showed recent BZD use is an independent risk for adverse respiratory events (OR = 2.70; 95% CI = 1.15–6.33; P < 0.001). Subgroup analysis showed both recent and long-term BZD use increased the risk of acute respiratory failure compared to never BZD use (OR = 28.6; 95% CI = 5.24–156; P < 0.001, OR = 10.1; 95% CI = 1.51–67.7; P < 0.05, respectively). Neither BZD nor non-BZD use increased the risk of pneumonia in OSA patients.Conclusion: BZD use might increase the risk of acute respiratory failure in OSA patients. |
| first_indexed | 2024-12-22T06:26:52Z |
| format | Article |
| id | doaj.art-a8951aa694f34248b75f0305433e10dc |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T06:26:52Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a8951aa694f34248b75f0305433e10dc2022-12-21T18:35:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-01-01910.3389/fphar.2018.01513420438Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep ApneaSheng-Huei Wang0Wei-Shan Chen1Wei-Shan Chen2Shih-En Tang3Hung-Che Lin4Hung-Che Lin5Chung-Kan Peng6Hsuan-Te Chu7Chia-Hung Kao8Chia-Hung Kao9Chia-Hung Kao10Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, TaiwanDepartment of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, TaiwanDepartment of Bioinformatics and Medical Engineering, Asia University, Taichung, TaiwanAims: Obstructive sleep apnea (OSA) and insomnia commonly coexist; hypnotics are broadly prescribed for insomnia therapy. However, the safety of hypnotics use in OSA patients is unclear. We conducted a retrospective case-control study to investigate the risk of adverse respiratory events in hypnotics-using OSA patients.Methods: We obtained data from the Taiwan National Health Insurance Database from 1996 to 2013. The case group included 216 OSA patients with newly diagnosed adverse respiratory events, including pneumonia and acute respiratory failure. The control group included OSA patients without adverse respiratory events, which was randomly frequency-matched to the case group at a 1:1 ratio according to age, gender, and index year. Hypnotics exposure included benzodiazepines (BZD) and non-benzodiazepines (non-BZD). A recent user was defined as a patient who had taken hypnotics for 1–30 days, while a long-term user was one who had taken hypnotics for 31–365 days.Results: Multivariable adjusted analysis showed recent BZD use is an independent risk for adverse respiratory events (OR = 2.70; 95% CI = 1.15–6.33; P < 0.001). Subgroup analysis showed both recent and long-term BZD use increased the risk of acute respiratory failure compared to never BZD use (OR = 28.6; 95% CI = 5.24–156; P < 0.001, OR = 10.1; 95% CI = 1.51–67.7; P < 0.05, respectively). Neither BZD nor non-BZD use increased the risk of pneumonia in OSA patients.Conclusion: BZD use might increase the risk of acute respiratory failure in OSA patients.https://www.frontiersin.org/article/10.3389/fphar.2018.01513/fullbenzodiazepineshypnoticsobstructive sleep apneaacute respiratory failurepneumonia |
| spellingShingle | Sheng-Huei Wang Wei-Shan Chen Wei-Shan Chen Shih-En Tang Hung-Che Lin Hung-Che Lin Chung-Kan Peng Hsuan-Te Chu Chia-Hung Kao Chia-Hung Kao Chia-Hung Kao Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea Frontiers in Pharmacology benzodiazepines hypnotics obstructive sleep apnea acute respiratory failure pneumonia |
| title | Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea |
| title_full | Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea |
| title_fullStr | Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea |
| title_full_unstemmed | Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea |
| title_short | Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea |
| title_sort | benzodiazepines associated with acute respiratory failure in patients with obstructive sleep apnea |
| topic | benzodiazepines hypnotics obstructive sleep apnea acute respiratory failure pneumonia |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01513/full |
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