Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial
IntroductionThe treatment effect of bright light therapy (BLT) on major depressive disorder (MDD) has been proven, but the underlying mechanism remains unclear. Neuroimaging biomarkers regarding disease alterations in MDD and treatment response are rarely focused on BLT. This study aimed to identify...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.979500/full |
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| author | Chun-Chao Huang Chun-Chao Huang Chun-Chao Huang Hui-Chun Huang Hui-Chun Huang Chen-Ju Lin Chen-Ju Lin Chien-Chi Hsu Chien-Chi Hsu Chau-Shoun Lee Chau-Shoun Lee Yu-Hsin Hsu Ting-Lin Chen Wei-Hsin Liao Yun-Hsiang Wu Fan-Pei Gloria Yang Fan-Pei Gloria Yang Fan-Pei Gloria Yang Shen-Ing Liu Shen-Ing Liu Shen-Ing Liu |
| author_facet | Chun-Chao Huang Chun-Chao Huang Chun-Chao Huang Hui-Chun Huang Hui-Chun Huang Chen-Ju Lin Chen-Ju Lin Chien-Chi Hsu Chien-Chi Hsu Chau-Shoun Lee Chau-Shoun Lee Yu-Hsin Hsu Ting-Lin Chen Wei-Hsin Liao Yun-Hsiang Wu Fan-Pei Gloria Yang Fan-Pei Gloria Yang Fan-Pei Gloria Yang Shen-Ing Liu Shen-Ing Liu Shen-Ing Liu |
| author_sort | Chun-Chao Huang |
| collection | DOAJ |
| description | IntroductionThe treatment effect of bright light therapy (BLT) on major depressive disorder (MDD) has been proven, but the underlying mechanism remains unclear. Neuroimaging biomarkers regarding disease alterations in MDD and treatment response are rarely focused on BLT. This study aimed to identify the modulatory mechanism of BLT in MDD using resting-state functional magnetic resonance imaging (rfMRI).Materials and methodsThis double-blind, randomized controlled clinical trial included a dim red light (dRL) control group and a BLT experimental group. All participants received light therapy for 30 min every morning for 4 weeks. The assessment of the Hamilton Depression Rating Scale-24 (HAMD-24) and brain MRI exam were performed at the baseline and the 4-week endpoint. The four networks in interest, including the default mode network (DMN), frontoparietal network (FPN), salience network (SN), and sensorimotor network (SMN), were analyzed. Between-group differences of the change in these four networks were evaluated.ResultsThere were 22 and 21 participants in the BLT and dRL groups, respectively. Age, sex, years of education, baseline severity, and improvement in depressive symptoms were not significantly different between the two groups. The baseline rfMRI data did not show any significant functional connectivity differences within the DMN, FPN, SN, and SMN between the two groups. Compared with the dRL group, the BTL group showed significantly increased functional connectivity after treatment within the DMN, FPN, SN, and SMN. Graph analysis of the BLT group demonstrated an enhancement of betweenness centrality and global efficiency.ConclusionBLT can enhance intra-network functional connectivity in the DMN, FPN, SN, and SMN for MDD patients. Furthermore, BLT improves the information processing of the whole brain.Clinical trial registrationThe ClinicalTrials.gov identifier was NCT03941301. |
| first_indexed | 2024-04-11T07:11:29Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T07:11:29Z |
| publishDate | 2022-11-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-a89703cc91394c2a9ea52cd248cbc6272022-12-22T04:38:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.979500979500Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trialChun-Chao Huang0Chun-Chao Huang1Chun-Chao Huang2Hui-Chun Huang3Hui-Chun Huang4Chen-Ju Lin5Chen-Ju Lin6Chien-Chi Hsu7Chien-Chi Hsu8Chau-Shoun Lee9Chau-Shoun Lee10Yu-Hsin Hsu11Ting-Lin Chen12Wei-Hsin Liao13Yun-Hsiang Wu14Fan-Pei Gloria Yang15Fan-Pei Gloria Yang16Fan-Pei Gloria Yang17Shen-Ing Liu18Shen-Ing Liu19Shen-Ing Liu20Department of Radiology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei, TaiwanMacKay Junior College of Medicine, Nursing and Management, Taipei, TaiwanMacKay Junior College of Medicine, Nursing and Management, Taipei, TaiwanDepartment of Medical Research, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Psychiatry, MacKay Memorial Hospital, Taipei, TaiwanInstitute of Health and Welfare Policy, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei, TaiwanDepartment of Psychiatry, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei, TaiwanDepartment of Psychiatry, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Counseling and Clinical Psychology, Teachers College, Columbia University, New York, NY, United StatesDepartment of Radiology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Radiology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, TaiwanDepartment of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, TaiwanCenter for Cognition and Mind Sciences, National Tsing Hua University, Hsinchu, Taiwan0Department of Radiology, Graduate School of Dentistry, Osaka University, Suita, JapanDepartment of Medicine, MacKay Medical College, New Taipei, TaiwanMacKay Junior College of Medicine, Nursing and Management, Taipei, TaiwanDepartment of Psychiatry, MacKay Memorial Hospital, Taipei, TaiwanIntroductionThe treatment effect of bright light therapy (BLT) on major depressive disorder (MDD) has been proven, but the underlying mechanism remains unclear. Neuroimaging biomarkers regarding disease alterations in MDD and treatment response are rarely focused on BLT. This study aimed to identify the modulatory mechanism of BLT in MDD using resting-state functional magnetic resonance imaging (rfMRI).Materials and methodsThis double-blind, randomized controlled clinical trial included a dim red light (dRL) control group and a BLT experimental group. All participants received light therapy for 30 min every morning for 4 weeks. The assessment of the Hamilton Depression Rating Scale-24 (HAMD-24) and brain MRI exam were performed at the baseline and the 4-week endpoint. The four networks in interest, including the default mode network (DMN), frontoparietal network (FPN), salience network (SN), and sensorimotor network (SMN), were analyzed. Between-group differences of the change in these four networks were evaluated.ResultsThere were 22 and 21 participants in the BLT and dRL groups, respectively. Age, sex, years of education, baseline severity, and improvement in depressive symptoms were not significantly different between the two groups. The baseline rfMRI data did not show any significant functional connectivity differences within the DMN, FPN, SN, and SMN between the two groups. Compared with the dRL group, the BTL group showed significantly increased functional connectivity after treatment within the DMN, FPN, SN, and SMN. Graph analysis of the BLT group demonstrated an enhancement of betweenness centrality and global efficiency.ConclusionBLT can enhance intra-network functional connectivity in the DMN, FPN, SN, and SMN for MDD patients. Furthermore, BLT improves the information processing of the whole brain.Clinical trial registrationThe ClinicalTrials.gov identifier was NCT03941301.https://www.frontiersin.org/articles/10.3389/fneur.2022.979500/fullbright light therapymajor depressive disorderfunctional MRIfunctional networkgraph theory |
| spellingShingle | Chun-Chao Huang Chun-Chao Huang Chun-Chao Huang Hui-Chun Huang Hui-Chun Huang Chen-Ju Lin Chen-Ju Lin Chien-Chi Hsu Chien-Chi Hsu Chau-Shoun Lee Chau-Shoun Lee Yu-Hsin Hsu Ting-Lin Chen Wei-Hsin Liao Yun-Hsiang Wu Fan-Pei Gloria Yang Fan-Pei Gloria Yang Fan-Pei Gloria Yang Shen-Ing Liu Shen-Ing Liu Shen-Ing Liu Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial Frontiers in Neurology bright light therapy major depressive disorder functional MRI functional network graph theory |
| title | Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial |
| title_full | Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial |
| title_fullStr | Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial |
| title_full_unstemmed | Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial |
| title_short | Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial |
| title_sort | subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder a double blind randomized controlled trial |
| topic | bright light therapy major depressive disorder functional MRI functional network graph theory |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.979500/full |
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