Correlation between Ferritin and Iron Overload in Heart and Liver in BetaThalassaemia Major Patients in Shahrekord, Iran
Introduction: Beta-thalassaemia is one of the severe types of thalassaemia with very high healthcare costs. Iron overload in heart and liver is the most fatal complication in betathalassemia. Aim: This study was performed to investigate the correlation between the heart and liver overload and bl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2018-07-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2300/24908_CE[VSU]_F(AnG)_PF1(VSU_AnG)_PFA(SHU)_PB(VSU_SHU)_PN(SS).pdf |
| Summary: | Introduction: Beta-thalassaemia is one of the severe types
of thalassaemia with very high healthcare costs. Iron overload
in heart and liver is the most fatal complication in betathalassemia.
Aim: This study was performed to investigate the correlation
between the heart and liver overload and blood ferritin level,
Nucleated Red Blood Cells (NRBCs) proportion, and other
effective factors involved.
Materials and Methods: In this descriptive-analytical study, 59
thalassaemia major patients were investigated. These patients
underwent transfusion 2-3 times a week and were enrolled in
the study by convenience, non random sampling. Iron overload
in heart and liver was measured by MRI T2*. Furthermore, some
variables such as haemoglobin level, transfusion intervals,
transfusion rate, spleen size, the type and dose of chelators,
and NRBCs as well as demographic variables including age,
gender, and race were analysed in this study. The data were
analysed by SPSS version 18.
Results: Our study showed that if there was a reduction in
NRBCs proportion, ferritin level and liver quantitative iron
overload decreased (p<0.05) and heart iron overload increased
(p<0.05). Also, an increment of ferritin level was correlated with
an increment of iron overload in heart and liver. Less mean
haemoglobin was correlated with decrease in liver iron overload
and increase in heart iron overload.
Conclusion: Ferritin could not be constantly used alone as a
suitable index of overload in liver and heart in beta-thalassaemia
major patients and it is necessary to take the specific conditions
of each patient into account and to use other parameters such
as haemoglobin and NRBCs proportion besides ferritin. |
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| ISSN: | 2277-8551 2455-6882 |