Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate
Aim :To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Materials and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Veterinary World
2013-05-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.veterinaryworld.org/Vol.6/August - 2013/Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate.pdf |
| Summary: | Aim :To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Materials and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily oral treatment regimes for 98 days. Group I served as control receiving only corn oil, group II received th chlorpyriphos @ 5.5 mg/ kg in corn oil, group III received lead acetate @100 ppm in water, whereas animals in group IV th received a combination of chlorpyriphos @ 5.5mg/kg in corn oil and lead acetate @ 100 ppm in water. Group V received th vitamin C @ 100mg/kg in water, group VI received a combination of chlorpyriphos @ 5.5mg/kg and vitamin C @ th th 100mg/kg , group VII received lead acetate @ 100 ppm in water and vitamin C @ 100mg/kg and group VIII received chlorpyriphos @ 5.5mg/kg , lead acetate @100ppm in water and vitamin C @ 100mg/kg. Results: Administration of both chlorpyriphos and lead acetate caused a significant decrease in oxidative stress parameters viz. blood glutathione, catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) along with a significant increase in lipid peroxidation level when given alone or in combination. Conclusions: The study demonstrated that treatment of chlorpyriphos and lead treated rats with vitamin C significantly improved some of altered oxidative stress parameters revealing the protective effect of this vitamin C against oxidative stress induced by chlorpyriphos and lead. [Vet World 2013; 6(8.000): 461-466] |
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| ISSN: | 0972-8988 2231-0916 |