Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil
OBJECTIVE: We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends. METHODS: The study included all consecutive patients treated at the A.C. Camargo Cancer Cen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2020-04-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100226&tlng=en |
| _version_ | 1811229545883238400 |
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| author | Luiz Paulo Kowalski Max Moura de Oliveira Rossana Veronica Mendoza Lopez Diego Rodrigues Mendonça e Silva Mauro Kazuo Ikeda Maria Paula Curado |
| author_facet | Luiz Paulo Kowalski Max Moura de Oliveira Rossana Veronica Mendoza Lopez Diego Rodrigues Mendonça e Silva Mauro Kazuo Ikeda Maria Paula Curado |
| author_sort | Luiz Paulo Kowalski |
| collection | DOAJ |
| description | OBJECTIVE: We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends. METHODS: The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models. RESULTS: Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year. CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients’ response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches. |
| first_indexed | 2024-04-12T10:17:07Z |
| format | Article |
| id | doaj.art-a899f7e931b04b9ab126aaa4776f0f80 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:17:07Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-a899f7e931b04b9ab126aaa4776f0f802022-12-22T03:37:11ZengElsevier EspañaClinics1980-53222020-04-017510.6061/clinics/2020/e1507Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, BrazilLuiz Paulo Kowalskihttps://orcid.org/0000-0002-0481-156XMax Moura de Oliveirahttps://orcid.org/0000-0002-0804-5145Rossana Veronica Mendoza Lopezhttps://orcid.org/0000-0001-7993-767XDiego Rodrigues Mendonça e Silvahttps://orcid.org/0000-0001-8469-8415Mauro Kazuo Ikedahttps://orcid.org/0000-0003-4807-8192Maria Paula Curadohttps://orcid.org/0000-0001-8172-2483OBJECTIVE: We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends. METHODS: The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models. RESULTS: Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year. CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients’ response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100226&tlng=enSurvival AnalysisPrognosisOral CavityOropharynxCancer |
| spellingShingle | Luiz Paulo Kowalski Max Moura de Oliveira Rossana Veronica Mendoza Lopez Diego Rodrigues Mendonça e Silva Mauro Kazuo Ikeda Maria Paula Curado Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil Clinics Survival Analysis Prognosis Oral Cavity Oropharynx Cancer |
| title | Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil |
| title_full | Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil |
| title_fullStr | Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil |
| title_full_unstemmed | Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil |
| title_short | Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil |
| title_sort | survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in sao paulo brazil |
| topic | Survival Analysis Prognosis Oral Cavity Oropharynx Cancer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100226&tlng=en |
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