The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma

The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma

Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS–ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS chaperone domain‐containing endochondral bone protein chondromodulin I (CHM...

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Bibliographic Details
Main Authors: Kristina vonHeyking, Julia Calzada‐Wack, Stefanie Göllner, Frauke Neff, Oxana Schmidt, Tim Hensel, David Schirmer, Annette Fasan, Irene Esposito, Carsten Müller‐Tidow, Poul H. Sorensen, Stefan Burdach, Günther H. S. Richter
Format: Article
Language:English
Published: Wiley 2017-09-01
Series:Molecular Oncology
Subjects:
CHM1
endochondral bone
Ewing sarcoma
invasion
metastasis
Online Access:https://doi.org/10.1002/1878-0261.12057

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