Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation
Mitochondria can produce the energy currency of the cell through respiration which would be affected by variation in mitochondrial DNA (mtDNA). We sequenced MT-ND3 and MT-ND4L genes in 51 Tibetan yaks, 59 Tibetan cattle, and 60 Holstein-Friesian. And the results showed that the SNPs (m.9893 A > G...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Mitochondrial DNA. Part B. Resources |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23802359.2018.1544040 |
| _version_ | 1797640577383137280 |
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| author | Xudong Mao Yu Shi Xiaohu Liang Mingcheng Cai Xue Yang Shiyi Chen Xianbo Jia Jie Wang Shenqiang Hu Songjia Lai |
| author_facet | Xudong Mao Yu Shi Xiaohu Liang Mingcheng Cai Xue Yang Shiyi Chen Xianbo Jia Jie Wang Shenqiang Hu Songjia Lai |
| author_sort | Xudong Mao |
| collection | DOAJ |
| description | Mitochondria can produce the energy currency of the cell through respiration which would be affected by variation in mitochondrial DNA (mtDNA). We sequenced MT-ND3 and MT-ND4L genes in 51 Tibetan yaks, 59 Tibetan cattle, and 60 Holstein-Friesian. And the results showed that the SNPs (m.9893 A > G, m.9932 A > C, and m.10155 C > T) of MT-ND3 had negative associations with high-altitude adaptation (p < .003), while the SNP m.10073C > T was positively associated with high-altitude adaptation (p < .0006). Haplotypes H1 and H5 in MT-ND3 and Ha1 in MT-ND4L showed positive associations with high-altitude adaptability, while haplotype H3 and Ha3 negatively associated with this adaptability (p < .0014, p < .0017). |
| first_indexed | 2024-03-11T13:33:44Z |
| format | Article |
| id | doaj.art-a89d754610824cc59df6ea5fbad0ea16 |
| institution | Directory Open Access Journal |
| issn | 2380-2359 |
| language | English |
| last_indexed | 2024-03-11T13:33:44Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mitochondrial DNA. Part B. Resources |
| spelling | doaj.art-a89d754610824cc59df6ea5fbad0ea162023-11-02T16:07:23ZengTaylor & Francis GroupMitochondrial DNA. Part B. Resources2380-23592019-01-014132432810.1080/23802359.2018.15440401544040Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptationXudong Mao0Yu Shi1Xiaohu Liang2Mingcheng Cai3Xue Yang4Shiyi Chen5Xianbo Jia6Jie Wang7Shenqiang Hu8Songjia Lai9Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityChengdu Academy of Agriculture and Forestry SciencesFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityMitochondria can produce the energy currency of the cell through respiration which would be affected by variation in mitochondrial DNA (mtDNA). We sequenced MT-ND3 and MT-ND4L genes in 51 Tibetan yaks, 59 Tibetan cattle, and 60 Holstein-Friesian. And the results showed that the SNPs (m.9893 A > G, m.9932 A > C, and m.10155 C > T) of MT-ND3 had negative associations with high-altitude adaptation (p < .003), while the SNP m.10073C > T was positively associated with high-altitude adaptation (p < .0006). Haplotypes H1 and H5 in MT-ND3 and Ha1 in MT-ND4L showed positive associations with high-altitude adaptability, while haplotype H3 and Ha3 negatively associated with this adaptability (p < .0014, p < .0017).http://dx.doi.org/10.1080/23802359.2018.1544040snphigh-altitude adaptationmt-nd3mt-nd4ltibetan cattle |
| spellingShingle | Xudong Mao Yu Shi Xiaohu Liang Mingcheng Cai Xue Yang Shiyi Chen Xianbo Jia Jie Wang Shenqiang Hu Songjia Lai Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation Mitochondrial DNA. Part B. Resources snp high-altitude adaptation mt-nd3 mt-nd4l tibetan cattle |
| title | Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation |
| title_full | Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation |
| title_fullStr | Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation |
| title_full_unstemmed | Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation |
| title_short | Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation |
| title_sort | genetic diversities of mt nd3 and mt nd4l genes are associated with high altitude adaptation |
| topic | snp high-altitude adaptation mt-nd3 mt-nd4l tibetan cattle |
| url | http://dx.doi.org/10.1080/23802359.2018.1544040 |
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