P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST
Background: prolonged circulatory unloading associated with head-down tilt bed rest (HDTBR) is followed by cardiovascular deconditioning. Aim of the study was to investigate to what extent large artery function and arterial-ventricular coupling (VA) are involved. Methods: ten healthy male voluntee...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125927337/view |
| _version_ | 1818216468241711104 |
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| author | F. Santini C. Morizzo E. Malshi M. Kozakova P. Salvi S. Pedri M. Pagani C. Palombo |
| author_facet | F. Santini C. Morizzo E. Malshi M. Kozakova P. Salvi S. Pedri M. Pagani C. Palombo |
| author_sort | F. Santini |
| collection | DOAJ |
| description | Background: prolonged circulatory unloading associated with head-down tilt bed rest (HDTBR) is followed by cardiovascular deconditioning.
Aim of the study was to investigate to what extent large artery function and arterial-ventricular coupling (VA) are involved.
Methods: ten healthy male volunteers (age 23±2) were studied before and after a 35-day HDTBR. Left ventricular (LV) volumes were investigated by echocardiography; carotid diameter and intima media thickness were assessed by high resolution ultrasound (Q-IMT, Esaote Europe). Contour Wave Analysis, performed by tonometer (PulsePen, DiaTecne, Milan Italy), was used to explore large artery function. Carotid-femoral pulse wave velocity (PWV) was also estimated (Complior, Alam, Paris).
Results: no changes were observed for systolic and diastolic blood pressure, PWV and QIMT vs baseline, while LV volumes showed a significant reduction (p<0.05). Arterial Elastance (Ea= end systolic pressure/stroke volume) and LV Elastance (Elv= end systolic pressure (ESP)/end systolic volume (ESV)) increased after HDTBR (for Ea: 1.08±0.198 vs 1.31±0.21, p=0.01; for Elv 1.478±0.32 vs 1.765±0.42, p=0.04) with unchanged Ea/Elv (0.74±0.09 vs 0.76±0.1). Contour wave analysis showed no significant changes for Augmentation Index (Aix), a reduction for PPI (Pulse Pressure Index: pulse pressure/mean arterial pressure, from 0.55±0.14 to 0.45±0.09, p<0.05), SEVR (subendocardial variability ratio: 1.84±0.33 vs 1.55±0.25, p=0.008) and LVET (left ventricular ejection time: 304.6±19.8 vs 291.5±11.2 ms, p=0.05), and an increase in heart rate (from 58±2 to 73±6, p<0.05).
Conclusions: no significant alterations in intrinsic arterial stiffness and structure were detected after HDTBR. The observed changes in large arteries function appear secondary to changes in LV performance. |
| first_indexed | 2024-12-12T06:52:27Z |
| format | Article |
| id | doaj.art-a89d905c61404635b39411896da03acf |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-12T06:52:27Z |
| publishDate | 2009-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-a89d905c61404635b39411896da03acf2022-12-22T00:34:02ZengBMCArtery Research1876-44012009-12-013410.1016/j.artres.2009.10.129P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED RESTF. SantiniC. MorizzoE. MalshiM. KozakovaP. SalviS. PedriM. PaganiC. PalomboBackground: prolonged circulatory unloading associated with head-down tilt bed rest (HDTBR) is followed by cardiovascular deconditioning. Aim of the study was to investigate to what extent large artery function and arterial-ventricular coupling (VA) are involved. Methods: ten healthy male volunteers (age 23±2) were studied before and after a 35-day HDTBR. Left ventricular (LV) volumes were investigated by echocardiography; carotid diameter and intima media thickness were assessed by high resolution ultrasound (Q-IMT, Esaote Europe). Contour Wave Analysis, performed by tonometer (PulsePen, DiaTecne, Milan Italy), was used to explore large artery function. Carotid-femoral pulse wave velocity (PWV) was also estimated (Complior, Alam, Paris). Results: no changes were observed for systolic and diastolic blood pressure, PWV and QIMT vs baseline, while LV volumes showed a significant reduction (p<0.05). Arterial Elastance (Ea= end systolic pressure/stroke volume) and LV Elastance (Elv= end systolic pressure (ESP)/end systolic volume (ESV)) increased after HDTBR (for Ea: 1.08±0.198 vs 1.31±0.21, p=0.01; for Elv 1.478±0.32 vs 1.765±0.42, p=0.04) with unchanged Ea/Elv (0.74±0.09 vs 0.76±0.1). Contour wave analysis showed no significant changes for Augmentation Index (Aix), a reduction for PPI (Pulse Pressure Index: pulse pressure/mean arterial pressure, from 0.55±0.14 to 0.45±0.09, p<0.05), SEVR (subendocardial variability ratio: 1.84±0.33 vs 1.55±0.25, p=0.008) and LVET (left ventricular ejection time: 304.6±19.8 vs 291.5±11.2 ms, p=0.05), and an increase in heart rate (from 58±2 to 73±6, p<0.05). Conclusions: no significant alterations in intrinsic arterial stiffness and structure were detected after HDTBR. The observed changes in large arteries function appear secondary to changes in LV performance.https://www.atlantis-press.com/article/125927337/view |
| spellingShingle | F. Santini C. Morizzo E. Malshi M. Kozakova P. Salvi S. Pedri M. Pagani C. Palombo P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST Artery Research |
| title | P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST |
| title_full | P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST |
| title_fullStr | P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST |
| title_full_unstemmed | P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST |
| title_short | P9.09 LARGE ARTERY FUNCTION AND VENTRICULAR ARTERIAL COUPLING DURING PROLONGED BED REST |
| title_sort | p9 09 large artery function and ventricular arterial coupling during prolonged bed rest |
| url | https://www.atlantis-press.com/article/125927337/view |
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