<i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization
Medicinal and aromatic plants are known to have a wide range of uses and health benefits, and should be exploited for their bioactivity. Here we evaluated the antimicrobial activity of decoctions of <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. against Gram-posit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/6/294 |
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| author | Fernanda Gomes Maria Inês Dias Ângela Lima Lillian Barros Maria Elisa Rodrigues Isabel C.F.R. Ferreira Mariana Henriques |
| author_facet | Fernanda Gomes Maria Inês Dias Ângela Lima Lillian Barros Maria Elisa Rodrigues Isabel C.F.R. Ferreira Mariana Henriques |
| author_sort | Fernanda Gomes |
| collection | DOAJ |
| description | Medicinal and aromatic plants are known to have a wide range of uses and health benefits, and should be exploited for their bioactivity. Here we evaluated the antimicrobial activity of decoctions of <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. against Gram-positive and Gram-negative bacteria and <i>Candida</i> spp. as well as their mechanism of action and phenolic characterization. The <i>Satureja montana</i> and <i>Origanum majorana</i> extracts were effective against a broad set of species, including the Gram-positive <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis,</i> and <i>Streptococcus dysgalactiae</i> and the Gram-negative <i>Klebsiella pneumoniae</i> and <i>Pseudomonas aeruginosa</i>. Both extracts were found to have rosmarinic acid as the main phenolic compound and to exert their antimicrobial activity at the level of the cell membrane. Membrane perturbations by the extracts impaired cell membrane integrity only a few hours after exposure. This study confirms the bioactive potential of <i>Satureja montana</i> and <i>Origanum majorana</i> decoctions, and supports the development of novel formulations with wide antimicrobial properties based on these medicinal and aromatic herbs. |
| first_indexed | 2024-03-10T19:27:58Z |
| format | Article |
| id | doaj.art-a89de684b7aa493fa5ba8cd967161fdf |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T19:27:58Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-a89de684b7aa493fa5ba8cd967161fdf2023-11-20T02:24:37ZengMDPI AGAntibiotics2079-63822020-05-019629410.3390/antibiotics9060294<i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic CharacterizationFernanda Gomes0Maria Inês Dias1Ângela Lima2Lillian Barros3Maria Elisa Rodrigues4Isabel C.F.R. Ferreira5Mariana Henriques6CEB, Centro de Engenharia Biológica, LIBRO–Laboratório de Investigação em Biofilmes Rosário Oliveira, Universidade do Minho, 4710-057 Braga, PortugalCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalCEB, Centro de Engenharia Biológica, LIBRO–Laboratório de Investigação em Biofilmes Rosário Oliveira, Universidade do Minho, 4710-057 Braga, PortugalCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalCEB, Centro de Engenharia Biológica, LIBRO–Laboratório de Investigação em Biofilmes Rosário Oliveira, Universidade do Minho, 4710-057 Braga, PortugalCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalCEB, Centro de Engenharia Biológica, LIBRO–Laboratório de Investigação em Biofilmes Rosário Oliveira, Universidade do Minho, 4710-057 Braga, PortugalMedicinal and aromatic plants are known to have a wide range of uses and health benefits, and should be exploited for their bioactivity. Here we evaluated the antimicrobial activity of decoctions of <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. against Gram-positive and Gram-negative bacteria and <i>Candida</i> spp. as well as their mechanism of action and phenolic characterization. The <i>Satureja montana</i> and <i>Origanum majorana</i> extracts were effective against a broad set of species, including the Gram-positive <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis,</i> and <i>Streptococcus dysgalactiae</i> and the Gram-negative <i>Klebsiella pneumoniae</i> and <i>Pseudomonas aeruginosa</i>. Both extracts were found to have rosmarinic acid as the main phenolic compound and to exert their antimicrobial activity at the level of the cell membrane. Membrane perturbations by the extracts impaired cell membrane integrity only a few hours after exposure. This study confirms the bioactive potential of <i>Satureja montana</i> and <i>Origanum majorana</i> decoctions, and supports the development of novel formulations with wide antimicrobial properties based on these medicinal and aromatic herbs.https://www.mdpi.com/2079-6382/9/6/294<i>Satureja montana</i><i>Origanum majorana</i>decoctionantimicrobial activitymechanism of actionphenolic characterization |
| spellingShingle | Fernanda Gomes Maria Inês Dias Ângela Lima Lillian Barros Maria Elisa Rodrigues Isabel C.F.R. Ferreira Mariana Henriques <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization Antibiotics <i>Satureja montana</i> <i>Origanum majorana</i> decoction antimicrobial activity mechanism of action phenolic characterization |
| title | <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization |
| title_full | <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization |
| title_fullStr | <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization |
| title_full_unstemmed | <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization |
| title_short | <i>Satureja montana</i> L. and <i>Origanum majorana</i> L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization |
| title_sort | i satureja montana i l and i origanum majorana i l decoctions antimicrobial activity mode of action and phenolic characterization |
| topic | <i>Satureja montana</i> <i>Origanum majorana</i> decoction antimicrobial activity mechanism of action phenolic characterization |
| url | https://www.mdpi.com/2079-6382/9/6/294 |
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