Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice
Background and Objectives: Epilepsy is the most common neurological disorder after stroke. Despite various anticonvulsants, researches continue to discover new drugs with better efficacy and less side-effects. Various herbs and natural substances with different properties are appropriate fields for...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2015-01-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| Subjects: | |
| Online Access: | http://journal.muq.ac.ir/article-1-198-en.html |
| _version_ | 1819067274535895040 |
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| author | Nasrin Heidarieh Maryam Najafifard Maryam Khoshsokhan Masomeh Najafifard Maryam Niksokhan |
| author_facet | Nasrin Heidarieh Maryam Najafifard Maryam Khoshsokhan Masomeh Najafifard Maryam Niksokhan |
| author_sort | Nasrin Heidarieh |
| collection | DOAJ |
| description | Background and Objectives: Epilepsy is the most common neurological disorder after stroke. Despite various anticonvulsants, researches continue to discover new drugs with better efficacy and less side-effects. Various herbs and natural substances with different properties are appropriate fields for such researches. This study investigated the effects of Aloe vera latex on seizure in male mice. Methods: Two groups of mice (n=8) and placebo were tested. The control group received Saline and the experimental group received Aloe vera latex (15, 25 and 50mg/kg) and half an hour later PTZ (80mg/kg) was injected intraperitoneally. Immediately after injection of PTZ, seizure threshold and duration of seizure were recorded. Data were analyzed by ANOVA and Tukey's test. p<0.05 was considered statistically significant. Results: The group receiving a 25mg/kg dose of Aloe vera latex showed a significant increase in seizure threshold and a significant decrease in duration of seizure as compared with placebo group receiving saline (p<0.05). Conclusion: The results of this study indicated the anticonvulsant effect of Aloe vera latex. |
| first_indexed | 2024-12-21T16:15:39Z |
| format | Article |
| id | doaj.art-a89deb9dc73c4063ac648dbb49bf00ef |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-21T16:15:39Z |
| publishDate | 2015-01-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-a89deb9dc73c4063ac648dbb49bf00ef2022-12-21T18:57:42ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752015-01-01863238Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male MiceNasrin Heidarieh0Maryam Najafifard1Maryam Khoshsokhan2Masomeh Najafifard3Maryam Niksokhan4 Islamic Azad University of Qom Islamic Azad University of Qom Islamic Azad University of Qom Islamic Azad University of Qom Islamic Azad University of Qom Background and Objectives: Epilepsy is the most common neurological disorder after stroke. Despite various anticonvulsants, researches continue to discover new drugs with better efficacy and less side-effects. Various herbs and natural substances with different properties are appropriate fields for such researches. This study investigated the effects of Aloe vera latex on seizure in male mice. Methods: Two groups of mice (n=8) and placebo were tested. The control group received Saline and the experimental group received Aloe vera latex (15, 25 and 50mg/kg) and half an hour later PTZ (80mg/kg) was injected intraperitoneally. Immediately after injection of PTZ, seizure threshold and duration of seizure were recorded. Data were analyzed by ANOVA and Tukey's test. p<0.05 was considered statistically significant. Results: The group receiving a 25mg/kg dose of Aloe vera latex showed a significant increase in seizure threshold and a significant decrease in duration of seizure as compared with placebo group receiving saline (p<0.05). Conclusion: The results of this study indicated the anticonvulsant effect of Aloe vera latex.http://journal.muq.ac.ir/article-1-198-en.htmlaloe verapentylenetetrazolseizuresmice |
| spellingShingle | Nasrin Heidarieh Maryam Najafifard Maryam Khoshsokhan Masomeh Najafifard Maryam Niksokhan Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum aloe vera pentylenetetrazol seizures mice |
| title | Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice |
| title_full | Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice |
| title_fullStr | Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice |
| title_full_unstemmed | Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice |
| title_short | Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice |
| title_sort | effect of the extract of aloe vera on the pentylenetetrazol induced seizure in male mice |
| topic | aloe vera pentylenetetrazol seizures mice |
| url | http://journal.muq.ac.ir/article-1-198-en.html |
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