Arterial spin labeling in the grading of brain gliomas: could it help?
Abstract Background Gliomas are characterized by high morbidity and mortality with low cure and high recurrence rates, which depends to a great degree on the angiogenesis of the tumor. Assessment of such angiogenesis by perfusion techniques is of utmost importance for the preoperative grading of gli...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-11-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43055-020-00352-6 |
| _version_ | 1818532254995972096 |
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| author | Ahmed A. ElBeheiry Doaa M. Emara Amany Abdel-Bary Abdel-Latif Mohamed Abbas Amal S. Ismail |
| author_facet | Ahmed A. ElBeheiry Doaa M. Emara Amany Abdel-Bary Abdel-Latif Mohamed Abbas Amal S. Ismail |
| author_sort | Ahmed A. ElBeheiry |
| collection | DOAJ |
| description | Abstract Background Gliomas are characterized by high morbidity and mortality with low cure and high recurrence rates, which depends to a great degree on the angiogenesis of the tumor. Assessment of such angiogenesis by perfusion techniques is of utmost importance for the preoperative grading of gliomas. The purpose of this study was to assess the role of arterial spin labeling (ASL) perfusion as a non-contrast MRI technique in the grading of brain gliomas, in correlation with the dynamic susceptibility contrast perfusion imaging (DSC-PI). The study was carried out on 35 patients admitted to the Neurosurgery Department with MRI features of gliomas and sent for further perfusion imaging. Non-contrast ASL followed by DSC-PI was done for all cases. The final diagnosis of the cases was established by histopathology. Results Fourteen patients (14/35) had low-grade gliomas while twenty-one (21/35) had high-grade gliomas. In low-grade gliomas, four cases out of 14 were falsely graded as high-grade tumors showing hyperperfusion on ASL, three of which showed DSC-PI hypoperfusion. In high-grade gliomas, two cases out of 21 were interpreted as an indeterminate grade by ASL showing isoperfusion, however showed hyperperfusion on DSC-PI. ROC curve analysis showed ASL-derived rCBF > 2.08 to have 80.95% sensitivity, 85.71% specificity, and overall accuracy of 82.86% compared to 100% sensitivity, specificity, and accuracy of DSC-PI-derived rCBV and rCBF of > 1.1 and > 0.9, respectively. A significant positive correlation was noted between ASL and DSC-PI with correlation coefficient reaching r = 0.80 between ASL-rCBF and DSC-rCBF (p < 0.01) and r = 0.68 between ASL and DSC-rCBV (p < 0.01). Conclusions ASL is a relatively recent non-contrast perfusion technique that obtains results which are in fair agreement with the more established DSC perfusion imaging making it an alternative method for preoperative assessment of perfusion of gliomas, especially for patients with contraindications to contrast agents. |
| first_indexed | 2024-12-11T17:43:06Z |
| format | Article |
| id | doaj.art-a8a0b8295db64a32a8c02635592dd0da |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-11T17:43:06Z |
| publishDate | 2020-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-a8a0b8295db64a32a8c02635592dd0da2022-12-22T00:56:28ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622020-11-0151111110.1186/s43055-020-00352-6Arterial spin labeling in the grading of brain gliomas: could it help?Ahmed A. ElBeheiry0Doaa M. Emara1Amany Abdel-Bary Abdel-Latif2Mohamed Abbas3Amal S. Ismail4Department of Radiodiagnosis, Faculty of Medicine, University of AlexandriaDepartment of Radiodiagnosis, Faculty of Medicine, University of AlexandriaDepartment of Pathology, Faculty of Medicine, University of AlexandriaDepartment of Neurosurgery, Faculty of Medicine, University of AlexandriaDepartment of Radiodiagnosis, Faculty of Medicine, University of AlexandriaAbstract Background Gliomas are characterized by high morbidity and mortality with low cure and high recurrence rates, which depends to a great degree on the angiogenesis of the tumor. Assessment of such angiogenesis by perfusion techniques is of utmost importance for the preoperative grading of gliomas. The purpose of this study was to assess the role of arterial spin labeling (ASL) perfusion as a non-contrast MRI technique in the grading of brain gliomas, in correlation with the dynamic susceptibility contrast perfusion imaging (DSC-PI). The study was carried out on 35 patients admitted to the Neurosurgery Department with MRI features of gliomas and sent for further perfusion imaging. Non-contrast ASL followed by DSC-PI was done for all cases. The final diagnosis of the cases was established by histopathology. Results Fourteen patients (14/35) had low-grade gliomas while twenty-one (21/35) had high-grade gliomas. In low-grade gliomas, four cases out of 14 were falsely graded as high-grade tumors showing hyperperfusion on ASL, three of which showed DSC-PI hypoperfusion. In high-grade gliomas, two cases out of 21 were interpreted as an indeterminate grade by ASL showing isoperfusion, however showed hyperperfusion on DSC-PI. ROC curve analysis showed ASL-derived rCBF > 2.08 to have 80.95% sensitivity, 85.71% specificity, and overall accuracy of 82.86% compared to 100% sensitivity, specificity, and accuracy of DSC-PI-derived rCBV and rCBF of > 1.1 and > 0.9, respectively. A significant positive correlation was noted between ASL and DSC-PI with correlation coefficient reaching r = 0.80 between ASL-rCBF and DSC-rCBF (p < 0.01) and r = 0.68 between ASL and DSC-rCBV (p < 0.01). Conclusions ASL is a relatively recent non-contrast perfusion technique that obtains results which are in fair agreement with the more established DSC perfusion imaging making it an alternative method for preoperative assessment of perfusion of gliomas, especially for patients with contraindications to contrast agents.http://link.springer.com/article/10.1186/s43055-020-00352-6Arterial spin labelingDynamic susceptibility contrast perfusion imagingGliomas |
| spellingShingle | Ahmed A. ElBeheiry Doaa M. Emara Amany Abdel-Bary Abdel-Latif Mohamed Abbas Amal S. Ismail Arterial spin labeling in the grading of brain gliomas: could it help? The Egyptian Journal of Radiology and Nuclear Medicine Arterial spin labeling Dynamic susceptibility contrast perfusion imaging Gliomas |
| title | Arterial spin labeling in the grading of brain gliomas: could it help? |
| title_full | Arterial spin labeling in the grading of brain gliomas: could it help? |
| title_fullStr | Arterial spin labeling in the grading of brain gliomas: could it help? |
| title_full_unstemmed | Arterial spin labeling in the grading of brain gliomas: could it help? |
| title_short | Arterial spin labeling in the grading of brain gliomas: could it help? |
| title_sort | arterial spin labeling in the grading of brain gliomas could it help |
| topic | Arterial spin labeling Dynamic susceptibility contrast perfusion imaging Gliomas |
| url | http://link.springer.com/article/10.1186/s43055-020-00352-6 |
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