OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION
Aim. Evaluation of the ability of the fixed combination of lisinopril, amlodipine and rosuvastatin (Equamer) in achievement of additional angioprotection in patients with systemic arterial hypertension (AH) and high pulse wave velocity (PWV), regardless of previous antihypertensive therapy (AHT).Mat...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2018-05-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2690 |
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| author | S. V. Nedogoda E. V. Chumachek A. A. Ledyaeva V. V. Tsoma A. S. Salasyuk V. O. Smirnova V. Yu. Hripaeva R. V. Palashkin E. A. Popova |
| author_facet | S. V. Nedogoda E. V. Chumachek A. A. Ledyaeva V. V. Tsoma A. S. Salasyuk V. O. Smirnova V. Yu. Hripaeva R. V. Palashkin E. A. Popova |
| author_sort | S. V. Nedogoda |
| collection | DOAJ |
| description | Aim. Evaluation of the ability of the fixed combination of lisinopril, amlodipine and rosuvastatin (Equamer) in achievement of additional angioprotection in patients with systemic arterial hypertension (AH) and high pulse wave velocity (PWV), regardless of previous antihypertensive therapy (AHT).Material and methods. To the open multicenter observational study 24 weeks duration, 60 patients included, taking double AHT during 6 months. All participants underwent ambulatory 24 hour blood pressure (BP) monitoring, applanation tonometry (augmentation index and central BP), pulse wave velocity assessment, laboratory tests (lipids, fasting glucose, insulin resistance index (HOMA), leptin, high sensitive C-reactive protein (hsCRP) before and after transition to the fixed combination of lisinopril, amlodipine and rosuvastatin (Equamer).Results. By the data from office BP measurement, after transition of patients from the double combinations to fixed combination of lisinopril, amlodipine and rosuvastatin, there was additional decrease of systolic BP (SBP) by 14,3% and diastolic BP (DBP) by 18,5%. By the data from ABPM, decrease of SBP was 16,1%, and DBP — 21,8%. Combination of lisinopril, amlodipine and rosuvastatin decreased PWV by 14,4%, augmentation index by 14,5%, central SBP by 8,1% (p<0,01 for all comparisons with baseline). Fixed combination of lisinopril, amlodipine and rosuvastatin made it to decrease low density lipoproteides by 44%, triglycerides by 36,1% and increase of high density lipoproteides by 10,3% (p<0,01 for all with baseline). Usage of combination of lisinopril, amlodipine and rosuvastatin showed significant decrease of insulin resistance, hsCRP and leptin levels.Conclusion. Fixed combination of lisinopril, amlodipine and rosuvastatin makes it to better control BP, improve vascular elasticity parameters (augmentation index, PWV, central BP) and facilitates the improvement of lipid and glucose metabolism, decrease of inflammation, leptin resistance in patients taking at baseline double antihypertensive therapy. |
| first_indexed | 2024-04-09T20:48:05Z |
| format | Article |
| id | doaj.art-a8a16641d2234312996e082731f9df7a |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:48:05Z |
| publishDate | 2018-05-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj.art-a8a16641d2234312996e082731f9df7a2023-03-29T21:23:30Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202018-05-0104495510.15829/1560-4071-2018-4-49-552349OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSIONS. V. Nedogoda0E. V. Chumachek1A. A. Ledyaeva2V. V. Tsoma3A. S. Salasyuk4V. O. Smirnova5V. Yu. Hripaeva6R. V. Palashkin7E. A. Popova8Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Volgograd State Medical University of the Ministry of Health.Aim. Evaluation of the ability of the fixed combination of lisinopril, amlodipine and rosuvastatin (Equamer) in achievement of additional angioprotection in patients with systemic arterial hypertension (AH) and high pulse wave velocity (PWV), regardless of previous antihypertensive therapy (AHT).Material and methods. To the open multicenter observational study 24 weeks duration, 60 patients included, taking double AHT during 6 months. All participants underwent ambulatory 24 hour blood pressure (BP) monitoring, applanation tonometry (augmentation index and central BP), pulse wave velocity assessment, laboratory tests (lipids, fasting glucose, insulin resistance index (HOMA), leptin, high sensitive C-reactive protein (hsCRP) before and after transition to the fixed combination of lisinopril, amlodipine and rosuvastatin (Equamer).Results. By the data from office BP measurement, after transition of patients from the double combinations to fixed combination of lisinopril, amlodipine and rosuvastatin, there was additional decrease of systolic BP (SBP) by 14,3% and diastolic BP (DBP) by 18,5%. By the data from ABPM, decrease of SBP was 16,1%, and DBP — 21,8%. Combination of lisinopril, amlodipine and rosuvastatin decreased PWV by 14,4%, augmentation index by 14,5%, central SBP by 8,1% (p<0,01 for all comparisons with baseline). Fixed combination of lisinopril, amlodipine and rosuvastatin made it to decrease low density lipoproteides by 44%, triglycerides by 36,1% and increase of high density lipoproteides by 10,3% (p<0,01 for all with baseline). Usage of combination of lisinopril, amlodipine and rosuvastatin showed significant decrease of insulin resistance, hsCRP and leptin levels.Conclusion. Fixed combination of lisinopril, amlodipine and rosuvastatin makes it to better control BP, improve vascular elasticity parameters (augmentation index, PWV, central BP) and facilitates the improvement of lipid and glucose metabolism, decrease of inflammation, leptin resistance in patients taking at baseline double antihypertensive therapy.https://russjcardiol.elpub.ru/jour/article/view/2690arterial hypertensionpulse wave velocitycentral arterial pressureaugmentation indexleptininflammationcombination antihypertension therapylisinoprilamlodipinerosuvastatin |
| spellingShingle | S. V. Nedogoda E. V. Chumachek A. A. Ledyaeva V. V. Tsoma A. S. Salasyuk V. O. Smirnova V. Yu. Hripaeva R. V. Palashkin E. A. Popova OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION Российский кардиологический журнал arterial hypertension pulse wave velocity central arterial pressure augmentation index leptin inflammation combination antihypertension therapy lisinopril amlodipine rosuvastatin |
| title | OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION |
| title_full | OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION |
| title_fullStr | OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION |
| title_full_unstemmed | OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION |
| title_short | OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION |
| title_sort | optimal organoprotection control of blood pressure and metabolic disorder with the fixed combination of lisinopril amlodipine and rosuvastatin in systemic hypertension |
| topic | arterial hypertension pulse wave velocity central arterial pressure augmentation index leptin inflammation combination antihypertension therapy lisinopril amlodipine rosuvastatin |
| url | https://russjcardiol.elpub.ru/jour/article/view/2690 |
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