Kinetoplastid membrane protein-11 exacerbates infection with Leishmania amazonensis in murine macrophages

Kinetoplastid membrane protein-11 exacerbates infection with Leishmania amazonensis in murine macrophages

In Leishmania amazonensis, kinetoplastid membrane protein-11 (KMP-11) expression increases during metacyclogenesis and is higher in amastigotes than in promastigotes, suggesting a role for this protein in the infection of the mammalian host. We show that the addition of KMP-11 exacerbates L. amazone...

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Bibliographic Details
Main Authors: Daniel Ignacchiti Lacerda, Léa Cysne-Finkelstein, Marise Pinheiro Nunes, Paula Mello De-Luca, Marcelo da Silva Genestra, Leonor Laura Pinto Leon, Marcia Berrêdo-Pinho, Leila Mendonça-Lima, Denise Cristina de Souza Matos, Marco Alberto Medeiros, Sergio Coutinho Furtado de Mendonça
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2012-03-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
kinetoplastid membrane protein-11
Leishmania amazonensis
macrophages
interleukin-10
nitric oxide
arginase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200014&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200014&lng=en&tlng=en

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