Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus)
Cypermethrin is a large spectrum action insecticide, globally employed to control pests in agriculture and some human and domestic animals ectoparasites. This study aimed to evaluate its toxicity and reproduction impairment in male guinea pig. Forty adult male guinea pigs were divided into 4 groups...
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Format: | Article |
Language: | English |
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Turkish Science and Technology Publishing (TURSTEP)
2018-02-01
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Series: | Turkish Journal of Agriculture: Food Science and Technology |
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Online Access: | http://www.agrifoodscience.com/index.php/TURJAF/article/view/1408 |
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author | Bertin Narcisse Vemo Augustave Kenfack Ferdinand Ngoula Edouard Akono Nantia Claude Cedric Njieudeu Ngaleu Arthénice Jemima Nounamo Guiekep Astride Martine Megnimeza Tsambou Ferry Nana Yidjeu Chancel Patrick Nelo Alexis Teguia |
author_facet | Bertin Narcisse Vemo Augustave Kenfack Ferdinand Ngoula Edouard Akono Nantia Claude Cedric Njieudeu Ngaleu Arthénice Jemima Nounamo Guiekep Astride Martine Megnimeza Tsambou Ferry Nana Yidjeu Chancel Patrick Nelo Alexis Teguia |
author_sort | Bertin Narcisse Vemo |
collection | DOAJ |
description | Cypermethrin is a large spectrum action insecticide, globally employed to control pests in agriculture and some human and domestic animals ectoparasites. This study aimed to evaluate its toxicity and reproduction impairment in male guinea pig. Forty adult male guinea pigs were divided into 4 groups and orally submitted to 0, 92, 137.5 and 275 mg/kg body weight/day for 90 days. The weight of the liver increased significantly, while that of kidneys decreased significantly in treated animals compared to controls. Serum concentrations of creatinine, urea, ALAT, ASAT, total cholesterol, prostatic acid phosphatase increased significantly, while the testicular total protein level decreased significantly in groups given the insecticide relatively to the control. The testes weight, libido, serum level of testosterone, mobility, sperm count and the percentage of spermatozoa with entire plasma membrane decreased significantly in animals exposed to cypermethrin with reference to controls. The percentages of abnormal spermatozoa increased significantly in animals submitted to 137.5 or 275 mg/kg body weight (bw) of cypermethrin compared to control ones. On the testis histological sections of pesticide-treated animals, immature germinal cells were observed in the lumen of seminiferous tubules. Cypermethrin was toxic in male guinea pig and damaged reproductive parameters. |
first_indexed | 2024-04-10T14:40:42Z |
format | Article |
id | doaj.art-a8a427e39c3146e8af42bc2829a2da8e |
institution | Directory Open Access Journal |
issn | 2148-127X |
language | English |
last_indexed | 2024-04-10T14:40:42Z |
publishDate | 2018-02-01 |
publisher | Turkish Science and Technology Publishing (TURSTEP) |
record_format | Article |
series | Turkish Journal of Agriculture: Food Science and Technology |
spelling | doaj.art-a8a427e39c3146e8af42bc2829a2da8e2023-02-15T16:08:12ZengTurkish Science and Technology Publishing (TURSTEP)Turkish Journal of Agriculture: Food Science and Technology2148-127X2018-02-016213013510.24925/turjaf.v6i2.130-135.1408779Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus)Bertin Narcisse Vemo0Augustave Kenfack1Ferdinand Ngoula2Edouard Akono Nantia3Claude Cedric Njieudeu Ngaleu4Arthénice Jemima Nounamo Guiekep5Astride Martine Megnimeza Tsambou6Ferry Nana Yidjeu7Chancel Patrick Nelo8Alexis Teguia9Department of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Biochemistry, Faculty of Sciences, University of Bamenda, Po Box 39, BambiliDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangDepartment of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Po Box 188 DschangCypermethrin is a large spectrum action insecticide, globally employed to control pests in agriculture and some human and domestic animals ectoparasites. This study aimed to evaluate its toxicity and reproduction impairment in male guinea pig. Forty adult male guinea pigs were divided into 4 groups and orally submitted to 0, 92, 137.5 and 275 mg/kg body weight/day for 90 days. The weight of the liver increased significantly, while that of kidneys decreased significantly in treated animals compared to controls. Serum concentrations of creatinine, urea, ALAT, ASAT, total cholesterol, prostatic acid phosphatase increased significantly, while the testicular total protein level decreased significantly in groups given the insecticide relatively to the control. The testes weight, libido, serum level of testosterone, mobility, sperm count and the percentage of spermatozoa with entire plasma membrane decreased significantly in animals exposed to cypermethrin with reference to controls. The percentages of abnormal spermatozoa increased significantly in animals submitted to 137.5 or 275 mg/kg body weight (bw) of cypermethrin compared to control ones. On the testis histological sections of pesticide-treated animals, immature germinal cells were observed in the lumen of seminiferous tubules. Cypermethrin was toxic in male guinea pig and damaged reproductive parameters.http://www.agrifoodscience.com/index.php/TURJAF/article/view/1408cypermethrinmale guinea pigreproduction impairmenttestosteronetoxicity |
spellingShingle | Bertin Narcisse Vemo Augustave Kenfack Ferdinand Ngoula Edouard Akono Nantia Claude Cedric Njieudeu Ngaleu Arthénice Jemima Nounamo Guiekep Astride Martine Megnimeza Tsambou Ferry Nana Yidjeu Chancel Patrick Nelo Alexis Teguia Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus) Turkish Journal of Agriculture: Food Science and Technology cypermethrin male guinea pig reproduction impairment testosterone toxicity |
title | Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus) |
title_full | Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus) |
title_fullStr | Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus) |
title_full_unstemmed | Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus) |
title_short | Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus) |
title_sort | toxicity and reproductive parameters impairment of cypermethrin in male guinea pig cavia porcellus |
topic | cypermethrin male guinea pig reproduction impairment testosterone toxicity |
url | http://www.agrifoodscience.com/index.php/TURJAF/article/view/1408 |
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