Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy

Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy

Abstract Background p-Boronophenylalanine (10BPA) is a powerful 10B drug used in current clinical trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of 10BPA must be administered over a few hours. Here, we report BNCT efficacy after rapid, ultralow-dose administration of either tumor...

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Bibliographic Details
Main Authors: Tohru Yoneyama, Shingo Hatakeyama, Mihoko Sutoh-Yoneyama, Taku Yoshiya, Tsuyoshi Uemura, Takehiro Ishizu, Minoru Suzuki, Shingo Hachinohe, Shintaro Ishiyama, Motohiro Nonaka, Michiko N. Fukuda, Chikara Ohyama
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Cancer
Subjects:
Drug delivery
Peptide
Annexin A1
Tumor vasculature
Boron neutron capture therapy
Online Access:https://doi.org/10.1186/s12885-020-07760-x

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