Zscan4 Contributes to Telomere Maintenance in Telomerase-Deficient Late Generation Mouse ESCs and Human ALT Cancer Cells

Zscan4 Contributes to Telomere Maintenance in Telomerase-Deficient Late Generation Mouse ESCs and Human ALT Cancer Cells

Proper telomere length is essential for indefinite self-renewal of embryonic stem (ES) cells and cancer cells. Telomerase-deficient late generation mouse ES cells and human ALT cancer cells are able to propagate for numerous passages, suggesting telomerase-independent mechanisms responding for telom...

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Bibliographic Details
Main Authors: Jiameng Dan, Zhongcheng Zhou, Fang Wang, Hua Wang, Renpeng Guo, David L. Keefe, Lin Liu
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
Zscan4
telomere
ES cells
ALT
DNA methylation
H3K9me3
Online Access:https://www.mdpi.com/2073-4409/11/3/456

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