Salvianolic acid B attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction via Nrf2-Gpx4 pathway-mediated ferroptosis

Salvianolic acid B attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction via Nrf2-Gpx4 pathway-mediated ferroptosis

Objective To determine the improving effect of salvianolic acid B on renal interstitial fibrosis (RIF) of rats with unilateral ureteral obstruction (UUO) based on ferroptosis mediated by nuclear factor erythroid 2-related factor 2 (Nrf2)-glutathione peroxidase 4 (Gpx4) pathway. Methods A total of 40...

Full description

Bibliographic Details
Main Authors:	SUN Yuanbo, SONG Yanran, WANG Shiqi, SUN Lixin, LI Guiqin
Format:	Article
Language:	zho
Published:	Editorial Office of Journal of Third Military Medical University 2022-05-01
Series:	Di-san junyi daxue xuebao
Subjects:	renal interstitial fibrosis unilateral ureteral obstruction salvianolic acid b nuclear factor erythroid 2-related factor 2-glutathione peroxidase 4 pathway
Online Access:	http://aammt.tmmu.edu.cn/Upload/rhtml/202110189.htm

Similar Items

<i>Thymus</i> spp. Aqueous Extracts and Their Constituent Salvianolic Acid A Induce Nrf2-Dependent Cellular Antioxidant Protection Against Oxidative Stress in Caco-2 Cells
by: Carlos Martins-Gomes, et al.
Published: (2024-10-01)

Ellagic acid ameliorates arsenic-induced neuronal ferroptosis and cognitive impairment via Nrf2/GPX4 signaling pathway
by: Xiyue Yang, et al.
Published: (2024-09-01)

Ciprofol prevents ferroptosis in LPS induced acute lung injury by activating the Nrf2 signaling pathway
by: Qin Zhao, et al.
Published: (2024-11-01)

Maresin-1 inhibits high glucose induced ferroptosis in ARPE-19 cells by activating the Nrf2/HO-1/GPX4 pathway
by: Yufei Li, et al.
Published: (2023-09-01)

Effect of high-dose N-acetyl cysteine on the clinical outcome of patients with diabetic peripheral neuropathy: a randomized controlled study
by: Sherien Mohamed Emara, et al.
Published: (2025-03-01)

Kidney tissue targeted metabolic profiling of unilateral ureteral obstruction rats by NMR
by: Zhen-Yu Li, et al.
Published: (2016-09-01)

Recombinant Newcastle disease virus rL-RVG induces ferroptosis of gastric cancer cells through inhibiting Nrf2-GCLC-GPX4 pathway
by: GONG Kewen, et al.
Published: (2024-07-01)

Modulation of Antioxidant Enzyme Expression of In Vitro Culture-Derived Reticulocytes
by: Hannah D. Langlands, et al.
Published: (2024-09-01)

Chosen Antioxidant Enzymes GPx4 and GPx8 in Human Colorectal Carcinoma: Study of the Slovak Population
by: Andriana Pavliuk-Karachevtseva, et al.
Published: (2022-02-01)

Pectolinarigenin Induces Antioxidant Enzymes through Nrf2/ARE Pathway in HepG2 Cells
by: Mariko Shiraiwa, et al.
Published: (2022-03-01)

N6-(2-Hydroxyethyl) Adenosine From Cordyceps cicadae Ameliorates Renal Interstitial Fibrosis and Prevents Inflammation via TGF-β1/Smad and NF-κB Signaling Pathway
by: Rong Zheng, et al.
Published: (2018-09-01)

Salvianolic acid B alleviates cartilage tissue damage in rat models with osteoarthritis
by: QIAN Ligang, SUN Bo, YU Bo, CHEN Kang, MA Zheng, CHEN Taoping, WANG Yunfei
Published: (2023-01-01)

Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway
by: Pinglan Lin, et al.
Published: (2023-12-01)

Targeting Nrf2 signaling in dry eye
by: Yu-Nuo Zhang, et al.
Published: (2024-10-01)

Epalrestat increases intracellular glutathione levels in Schwann cells through transcription regulation
by: Keisuke Sato, et al.
Published: (2014-01-01)

GPX1 Localizes to the Nucleus in Prostate Epithelium and its Levels are not Associated with Prostate Cancer Recurrence
by: Dede N. Ekoue, et al.
Published: (2018-11-01)

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis
by: Giovanni Tossetta, et al.
Published: (2024-10-01)

The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway
by: Giuseppe Caruso, et al.
Published: (2022-07-01)

Salvianolic acids and its potential for cardio-protection against myocardial ischemic reperfusion injury in diabetes
by: Yuxin Jiang, et al.
Published: (2024-01-01)

The Effect of Estradiol on Oxidative Stress Index and Nitric Oxide Levels in Unilateral Ureteral Obstruction in Ovariectomized Rats
by: Z Lak, et al.
Published: (2022-03-01)

Effect of Ethanol Extract of Basil Leaves (Ocimum basilicum) on the number of M2 Macrophages in the Kidneys of Mice (Mus musculus) Using the Unilateral Ureteral Obstruction (UUO) Method
by: Muhammad Achya Farhany, et al.
Published: (2022-08-01)

Salvianolic acid B improves glucolipid metabolism by regulating adipogenic transcription factors in mice with diet-induced obesity
by: Dandan Zhao, et al.
Published: (2017-07-01)

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments
by: Elena Martínez-Klimova, et al.
Published: (2019-04-01)

Efficacy and safety of salvianolate injection in treating acute myocardial infarction: a meta-analysis and systematic literature review
by: Pengfei Chen, et al.
Published: (2024-12-01)

Lymphoid-specific helicase inhibits cervical cancer cells ferroptosis by promoting Nrf2 expression
by: Weiwei Tie, et al.
Published: (2023-11-01)

S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway
by: Wei-Jun Wu, et al.
Published: (2016-12-01)

Current Landscape of NRF2 Biomarkers in Clinical Trials
by: Yoko Yagishita, et al.
Published: (2020-08-01)

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies
by: Morana Jaganjac, et al.
Published: (2020-11-01)

The Role of Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches
by: Yu Wang, et al.
Published: (2022-08-01)

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
by: Xiaohua Song, et al.
Published: (2020-04-01)

Salvianolic Acid B Inhibits Activation of Human Primary Hepatic Stellate Cells Through Downregulation of the Myocyte Enhancer Factor 2 Signaling Pathway
by: Wenwei Zhang, et al.
Published: (2019-04-01)

Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators
by: Yu-Tse Kao, et al.
Published: (2020-07-01)

Inhibition of Melanoma Cell Growth by Salvianolic Acid A through CHK2-CDC25A Pathway Modulation
by: Xiao-Yan Pu, et al.
Published: (2024-06-01)

Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis
by: Ji Zhu, et al.
Published: (2022-11-01)

Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases
by: Tarun Pant, et al.
Published: (2024-04-01)

Expression of Nrf2 in Different Cells after Human Cerebral Cortex Contusion
by: GUO Xiang-shen, WEN Shu-heng, DONG Wen-wen，et al.
Published: (2019-06-01)

Nrf2 regulates the activation of THP-1 cells induced by chloral hydrate
by: Jinfeng Zhao, et al.
Published: (2023-05-01)

Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation
by: Shiwen Fan, et al.
Published: (2024-11-01)

The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression
by: Seokwoo Park, et al.
Published: (2025-04-01)

Exploration of the Mechanism of Salvianolic Acid for Injection Against Ischemic Stroke: A Research Based on Computational Prediction and Experimental Validation
by: Xiaoqiang Li, et al.
Published: (2022-05-01)