The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome

The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome

<b>Background:</b> Given the role of the P2X7 receptor (P2X7R) in inflammatory bowel diseases (IBD), we investigated its role in the development and progression of colitis-associated colorectal cancer (CA-CRC). <b>Methods:</b> CA-CRC was induced in P2X7R<sup>+/+</sup...

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Bibliographic Details
Main Authors: Claudio Bernardazzi, Morgana Teixeira Lima Castelo-Branco, Beatriz Pêgo, Beatriz Elias Ribeiro, Siane Lopes Bittencourt Rosas, Patrícia Teixeira Santana, João Carlos Machado, Camille Leal, Fabiano Thompson, Robson Coutinho-Silva, Heitor Siffert Pereira de Souza
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
colitis-associated colorectal cancer
gut microbiota
inflammatory bowel disease
P2X7R
purinergic signaling
Online Access:https://www.mdpi.com/1422-0067/23/9/4616

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