ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIAL
the treatment with antibiotics represents one of the main components of the medical treatment of neglected peritonitises. Material and method: in principle, the antibiotics therapy must take place based on the bacteriological examination and with the results of the antibiogram in mind. However, i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Romanian Dental Association for Education
2013-01-01
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| Series: | Romanian Journal of Medical and Dental Education |
| Subjects: | |
| Online Access: | http://journal.adre.ro/antibiotic-therapy-of-neglected-peritonitises-clinical-trial-2/ |
| _version_ | 1828530032133275648 |
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| author | Gabriel STATESCU Mihaela CARAUSU |
| author_facet | Gabriel STATESCU Mihaela CARAUSU |
| author_sort | Gabriel STATESCU |
| collection | DOAJ |
| description | the treatment with antibiotics represents one of the main components of the medical
treatment of neglected peritonitises. Material and method: in principle, the antibiotics therapy must
take place based on the bacteriological examination and with the results of the antibiogram in mind.
However, in practice, because of the emergency situation and the polymorphism of bacteria we could
also apply certain theoretical criteria in order to properly select the antibiotics treatment, but: the
antibiotic must be active for the peritonitis germs; it must have a good penetration and it must
concentrate in the peritoneal cavity; it must not any have toxic effects and must not be conducive to
kidney failure. In our trial we have used a systematic antibiotics treatment in emergency situations, and
we have often chosen combination of antibiotics following the analysis of the peritoneal pus and the
antibiogram outcome. Results: The antibiotics used the most were Penicillin, Gentamicin,
Metronidazole and Ampicillin. The combination of three antibiotics was used in 67.35% of all the
cases when antibiotics were used. The antibiotics mostly used in an association of two were:
Penicillin, Gentamicin, Ceftriaxone, Cefazolin. This association was used in 26.53% of the cases
when antibiotics were used in the treatment. The most frequent antibiotics used in a combination of
two for the treatment of acute appendicitis were: Ampicillin and Gentamicin, respectively
Ampicillin and Metronidazole. The percentage of this association of the whole antibiotherapy for
acute appendicitis represents 23.81%. In our trial we have compared the therapeutic proficiency
of one antibiotic vs the combination of antibiotics in cases of neglected peritonitises. From our
results we have found that there was an increased sensibility and a high rate of response (92%) in
the patients treated with Imipenem and Netilmicin, in comparison with the rate of positive
response of 83%, which we achieved when Imipenem was administrated in monotherapy.
Conclusions: We have applied an algorithm of antibiotics therapy in a growing scale: Tienam
(Imipenem) usually, in the 3 days until we have obtained the result of the antibiogram and we
have become aware of the sensibility of the bacteria and had the possibility to choose a
combination of antibiotics. |
| first_indexed | 2024-12-11T22:17:20Z |
| format | Article |
| id | doaj.art-a8ae4e653e1f477ba16804ca1f6cc880 |
| institution | Directory Open Access Journal |
| issn | 2393-1531 2393-1108 |
| language | English |
| last_indexed | 2024-12-11T22:17:20Z |
| publishDate | 2013-01-01 |
| publisher | Romanian Dental Association for Education |
| record_format | Article |
| series | Romanian Journal of Medical and Dental Education |
| spelling | doaj.art-a8ae4e653e1f477ba16804ca1f6cc8802022-12-22T00:48:34ZengRomanian Dental Association for EducationRomanian Journal of Medical and Dental Education2393-15312393-11082013-01-01116367ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIALGabriel STATESCU0Mihaela CARAUSU1Military Emergency Hospital „Dr.Iacob Czihac” Iasi”Grigore T.Popa” University of Medicine and Pharmacy Iasi, Romania Faculty of Dental Medicine, Public Health and Management Dept.the treatment with antibiotics represents one of the main components of the medical treatment of neglected peritonitises. Material and method: in principle, the antibiotics therapy must take place based on the bacteriological examination and with the results of the antibiogram in mind. However, in practice, because of the emergency situation and the polymorphism of bacteria we could also apply certain theoretical criteria in order to properly select the antibiotics treatment, but: the antibiotic must be active for the peritonitis germs; it must have a good penetration and it must concentrate in the peritoneal cavity; it must not any have toxic effects and must not be conducive to kidney failure. In our trial we have used a systematic antibiotics treatment in emergency situations, and we have often chosen combination of antibiotics following the analysis of the peritoneal pus and the antibiogram outcome. Results: The antibiotics used the most were Penicillin, Gentamicin, Metronidazole and Ampicillin. The combination of three antibiotics was used in 67.35% of all the cases when antibiotics were used. The antibiotics mostly used in an association of two were: Penicillin, Gentamicin, Ceftriaxone, Cefazolin. This association was used in 26.53% of the cases when antibiotics were used in the treatment. The most frequent antibiotics used in a combination of two for the treatment of acute appendicitis were: Ampicillin and Gentamicin, respectively Ampicillin and Metronidazole. The percentage of this association of the whole antibiotherapy for acute appendicitis represents 23.81%. In our trial we have compared the therapeutic proficiency of one antibiotic vs the combination of antibiotics in cases of neglected peritonitises. From our results we have found that there was an increased sensibility and a high rate of response (92%) in the patients treated with Imipenem and Netilmicin, in comparison with the rate of positive response of 83%, which we achieved when Imipenem was administrated in monotherapy. Conclusions: We have applied an algorithm of antibiotics therapy in a growing scale: Tienam (Imipenem) usually, in the 3 days until we have obtained the result of the antibiogram and we have become aware of the sensibility of the bacteria and had the possibility to choose a combination of antibiotics.http://journal.adre.ro/antibiotic-therapy-of-neglected-peritonitises-clinical-trial-2/neglected peritonitisesantibiotics therapyimipenem |
| spellingShingle | Gabriel STATESCU Mihaela CARAUSU ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIAL Romanian Journal of Medical and Dental Education neglected peritonitises antibiotics therapy imipenem |
| title | ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIAL |
| title_full | ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIAL |
| title_fullStr | ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIAL |
| title_full_unstemmed | ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIAL |
| title_short | ANTIBIOTIC THERAPY OF NEGLECTED PERITONITISES – CLINICAL TRIAL |
| title_sort | antibiotic therapy of neglected peritonitises clinical trial |
| topic | neglected peritonitises antibiotics therapy imipenem |
| url | http://journal.adre.ro/antibiotic-therapy-of-neglected-peritonitises-clinical-trial-2/ |
| work_keys_str_mv | AT gabrielstatescu antibiotictherapyofneglectedperitonitisesclinicaltrial AT mihaelacarausu antibiotictherapyofneglectedperitonitisesclinicaltrial |