Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension
Objective: To investigate the correlation between transient receptor potential channel 1 (TRPC1) gene polymorphism and microalbuminuria in patients with primary hypertension. Methods: A total of 468 patients with primary hypertension were admitted to the Department of Hypertension of the First Affil...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-07-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2021.1901107 |
| _version_ | 1797681316448174080 |
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| author | Yu Zhang Bumairemu Maitikuerban Yulan Chen Yu Li Yaping Cao Xinjuan Xu |
| author_facet | Yu Zhang Bumairemu Maitikuerban Yulan Chen Yu Li Yaping Cao Xinjuan Xu |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Objective: To investigate the correlation between transient receptor potential channel 1 (TRPC1) gene polymorphism and microalbuminuria in patients with primary hypertension. Methods: A total of 468 patients with primary hypertension were admitted to the Department of Hypertension of the First Affiliated Hospital of Xinjiang Medical University from April 2015 to November 2017. According to microalbuminuria, the patients were divided into two groups: high urinary albumin group (EH+mALB group, n = 71) and normal urinary microalbuminuria group (EH group, n = 397). The Sequenom detection technology was used for genotyping the single nucleotide polymorphism (SNP) sites of the TRPC1 gene, such as rs1382688, rs3821647, rs7638459, rs953239, and rs7621642. Results: (1) No significant differences were detected in gender, smoking history, drinking history, family history, course of hypertension, fasting blood glucose, urea, creatinine, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glycosylated hemoglobin, vitamin D, homocysteine, and cystatin C between the two groups (P > .05). However, age, body mass index (BMI), 24-h mean systolic and diastolic blood pressure, and 24-h average pulse pressure were statistically significant (P < .05). (2) No significant difference was detected in the distribution frequency of the polymorphisms of the TRPC1 gene between the two groups (P > .05), while the genotype, allele, and recessive model of rs7638459 differed significantly difference (P < .05). (3) Logistic regression analysis showed that BMI and rs7638459 CC genotype were the risk factors of increased microalbuminuria in patients with primary hypertension. Conclusion: TRPC1 gene polymorphism is associated with increased microalbuminuria in patients with primary hypertension. The CC genotype of rs7638459 may increase the risk of microalbuminuria in patients with essential hypertension, while BMI and rs7638459 CC genotype may be the risk factors of increased microalbuminuria in patients with primary hypertension. |
| first_indexed | 2024-03-11T23:43:10Z |
| format | Article |
| id | doaj.art-a8af971402824657a7c932b87f570998 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:10Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-a8af971402824657a7c932b87f5709982023-09-19T15:19:29ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062021-07-0143544344910.1080/10641963.2021.19011071901107Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertensionYu Zhang0Bumairemu Maitikuerban1Yulan Chen2Yu Li3Yaping Cao4Xinjuan Xu5The First Affiliated Hospital of Xinjiang Medical UniversityHetian Region People’s HospitalThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityObjective: To investigate the correlation between transient receptor potential channel 1 (TRPC1) gene polymorphism and microalbuminuria in patients with primary hypertension. Methods: A total of 468 patients with primary hypertension were admitted to the Department of Hypertension of the First Affiliated Hospital of Xinjiang Medical University from April 2015 to November 2017. According to microalbuminuria, the patients were divided into two groups: high urinary albumin group (EH+mALB group, n = 71) and normal urinary microalbuminuria group (EH group, n = 397). The Sequenom detection technology was used for genotyping the single nucleotide polymorphism (SNP) sites of the TRPC1 gene, such as rs1382688, rs3821647, rs7638459, rs953239, and rs7621642. Results: (1) No significant differences were detected in gender, smoking history, drinking history, family history, course of hypertension, fasting blood glucose, urea, creatinine, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glycosylated hemoglobin, vitamin D, homocysteine, and cystatin C between the two groups (P > .05). However, age, body mass index (BMI), 24-h mean systolic and diastolic blood pressure, and 24-h average pulse pressure were statistically significant (P < .05). (2) No significant difference was detected in the distribution frequency of the polymorphisms of the TRPC1 gene between the two groups (P > .05), while the genotype, allele, and recessive model of rs7638459 differed significantly difference (P < .05). (3) Logistic regression analysis showed that BMI and rs7638459 CC genotype were the risk factors of increased microalbuminuria in patients with primary hypertension. Conclusion: TRPC1 gene polymorphism is associated with increased microalbuminuria in patients with primary hypertension. The CC genotype of rs7638459 may increase the risk of microalbuminuria in patients with essential hypertension, while BMI and rs7638459 CC genotype may be the risk factors of increased microalbuminuria in patients with primary hypertension.http://dx.doi.org/10.1080/10641963.2021.1901107trpc1 genesingle nucleotide polymorphismmicroalbuminuriaprimary hypertension |
| spellingShingle | Yu Zhang Bumairemu Maitikuerban Yulan Chen Yu Li Yaping Cao Xinjuan Xu Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension Clinical and Experimental Hypertension trpc1 gene single nucleotide polymorphism microalbuminuria primary hypertension |
| title | Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension |
| title_full | Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension |
| title_fullStr | Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension |
| title_full_unstemmed | Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension |
| title_short | Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension |
| title_sort | correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension |
| topic | trpc1 gene single nucleotide polymorphism microalbuminuria primary hypertension |
| url | http://dx.doi.org/10.1080/10641963.2021.1901107 |
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