Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, Nizamabad
Background: Mucormycosis is a rare, opportunistic fungal infection with high morbidity and mortality. Coronavirus disease 2019 (COVID-19) associated mucormycosis has been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes and systemic corticosteroid trea...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-02-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/48697 |
| _version_ | 1797937055788957696 |
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| author | Manisha Thavanam Farida Begum Seshava Puri Smitha Vadana Nagarjuna Chary Rajarikam Harish Swamy Dharmagadda |
| author_facet | Manisha Thavanam Farida Begum Seshava Puri Smitha Vadana Nagarjuna Chary Rajarikam Harish Swamy Dharmagadda |
| author_sort | Manisha Thavanam |
| collection | DOAJ |
| description | Background: Mucormycosis is a rare, opportunistic fungal infection with high morbidity and mortality. Coronavirus disease 2019 (COVID-19) associated mucormycosis has been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes and systemic corticosteroid treatment.
Aims and Objectives: The aim of the study was to study mucormycosis occurrence in COVID-19 patients at Government General Hospital, Nizamabad – A tertiary care center and to correlate mucormycosis with comorbidities and previous treatment modalities among admitted post COVID-19 patients.
Materials and Methods: Cross-sectional retrospective study was done for 3 months, from June 2021 to August 2021. Fifty suspected cases of mucormycosis specimens sent to the Department of Pathology, Government General Hospital, Nizamabad for histopathological diagnosis were considered. Clinical history and treatment details were noted. Tissues obtained were fixed in 10% formalin, routine hematoxylin and eosin (H&E) stains were done. Gomori’s methenamine silver stains were done.
Results: Mucormycosis was most common in males 37 (74%) and common in the age group of 41–50 years (26%). Diabetes mellitus is the most common comorbidity (60%). The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 6–40 days. Out of 50 cases, 46 patients received steroid therapy and 39 cases were given oxygen support.
Conclusion: Mucormycosis is a rapidly progressive life-threatening opportunistic infection. Post COVID-19 patients with uncontrolled diabetes are more prone to it and an important predisposing factor. Treatment with steroid therapy and oxygen support must be carefully monitored and used in a vigilant manner. Histopathological examination and clinical correlation are essential for early diagnosis and treatment. |
| first_indexed | 2024-04-10T18:38:46Z |
| format | Article |
| id | doaj.art-a8b1f4b19ee74acfbcb102c9029ce5d4 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-10T18:38:46Z |
| publishDate | 2023-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-a8b1f4b19ee74acfbcb102c9029ce5d42023-02-01T23:31:27ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-02-011422227https://doi.org/10.3126/ajms.v14i2.48697Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, NizamabadManisha Thavanam 0https://orcid.org/0000-0003-3137-1982Farida Begum 1https://orcid.org/0000-0002-5370-1420Seshava Puri Smitha Vadana 2https://orcid.org/0000-0002-3819-7430Nagarjuna Chary Rajarikam 3https://orcid.org/0000-0003-4297-9686Harish Swamy Dharmagadda 4https://orcid.org/0000-0001-9262-9321Postgraduate Resident, Department of Pathology, Government Medical College, Nizamabad, Telangana, India Associate Professor, Department of Pathology, Government Medical College, Nizamabad, Telangana, India Assistant Professor, Department of Pathology, Government Medical College, Nizamabad, Telangana, India Professor and Head, Department of Pathology, Government Medical College, Nizamabad, Telangana, India Assistant Professor, Department of ENT, Government Medical College, Nizamabad, Telangana, India Background: Mucormycosis is a rare, opportunistic fungal infection with high morbidity and mortality. Coronavirus disease 2019 (COVID-19) associated mucormycosis has been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes and systemic corticosteroid treatment. Aims and Objectives: The aim of the study was to study mucormycosis occurrence in COVID-19 patients at Government General Hospital, Nizamabad – A tertiary care center and to correlate mucormycosis with comorbidities and previous treatment modalities among admitted post COVID-19 patients. Materials and Methods: Cross-sectional retrospective study was done for 3 months, from June 2021 to August 2021. Fifty suspected cases of mucormycosis specimens sent to the Department of Pathology, Government General Hospital, Nizamabad for histopathological diagnosis were considered. Clinical history and treatment details were noted. Tissues obtained were fixed in 10% formalin, routine hematoxylin and eosin (H&E) stains were done. Gomori’s methenamine silver stains were done. Results: Mucormycosis was most common in males 37 (74%) and common in the age group of 41–50 years (26%). Diabetes mellitus is the most common comorbidity (60%). The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 6–40 days. Out of 50 cases, 46 patients received steroid therapy and 39 cases were given oxygen support. Conclusion: Mucormycosis is a rapidly progressive life-threatening opportunistic infection. Post COVID-19 patients with uncontrolled diabetes are more prone to it and an important predisposing factor. Treatment with steroid therapy and oxygen support must be carefully monitored and used in a vigilant manner. Histopathological examination and clinical correlation are essential for early diagnosis and treatment.https://www.nepjol.info/index.php/AJMS/article/view/48697covid-19; diabetes mellitus; immunosuppression; mucormycosis |
| spellingShingle | Manisha Thavanam Farida Begum Seshava Puri Smitha Vadana Nagarjuna Chary Rajarikam Harish Swamy Dharmagadda Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, Nizamabad Asian Journal of Medical Sciences covid-19; diabetes mellitus; immunosuppression; mucormycosis |
| title | Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, Nizamabad |
| title_full | Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, Nizamabad |
| title_fullStr | Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, Nizamabad |
| title_full_unstemmed | Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, Nizamabad |
| title_short | Clinico-pathological study of mucormycosis in post-COVID patients at government general hospital, Nizamabad |
| title_sort | clinico pathological study of mucormycosis in post covid patients at government general hospital nizamabad |
| topic | covid-19; diabetes mellitus; immunosuppression; mucormycosis |
| url | https://www.nepjol.info/index.php/AJMS/article/view/48697 |
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