Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer
The ubiquitin (Ub)–proteasome system (UPS) is an important regulatory component in colorectal cancer (CRC), and the cell cycle is also characterized to play a significant role in CRC. In this present study, we firstly identified UPS-associated differentially expressed genes and all the differentiall...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.653528/full |
| _version_ | 1819103648825737216 |
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| author | Zhiyuan Zhang Jingwen Chen Wentao Tang Qingyang Feng Jianmin Xu Li Ren |
| author_facet | Zhiyuan Zhang Jingwen Chen Wentao Tang Qingyang Feng Jianmin Xu Li Ren |
| author_sort | Zhiyuan Zhang |
| collection | DOAJ |
| description | The ubiquitin (Ub)–proteasome system (UPS) is an important regulatory component in colorectal cancer (CRC), and the cell cycle is also characterized to play a significant role in CRC. In this present study, we firstly identified UPS-associated differentially expressed genes and all the differentially expressed protein-coding genes in CRC through three differential analyses. UPS-associated genes were also further analyzed via survival analysis. A weighted gene co-expression network analysis (WGCNA) was used to identify the cell cycle-associated genes. We used protein–protein interaction (PPI) network to comprehensively mine the potential mechanism of the UPS–cell cycle regulatory axis. Moreover, we constructed a signature based on UPS-associated genes to predict the overall survival of CRC patients. Our research provides a novel insight view of the UPS and cell cycle system in CRC. |
| first_indexed | 2024-12-22T01:53:48Z |
| format | Article |
| id | doaj.art-a8b3665b9d514a9e88346afd13b946bb |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T01:53:48Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a8b3665b9d514a9e88346afd13b946bb2022-12-21T18:42:51ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-06-01910.3389/fcell.2021.653528653528Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal CancerZhiyuan ZhangJingwen ChenWentao TangQingyang FengJianmin XuLi RenThe ubiquitin (Ub)–proteasome system (UPS) is an important regulatory component in colorectal cancer (CRC), and the cell cycle is also characterized to play a significant role in CRC. In this present study, we firstly identified UPS-associated differentially expressed genes and all the differentially expressed protein-coding genes in CRC through three differential analyses. UPS-associated genes were also further analyzed via survival analysis. A weighted gene co-expression network analysis (WGCNA) was used to identify the cell cycle-associated genes. We used protein–protein interaction (PPI) network to comprehensively mine the potential mechanism of the UPS–cell cycle regulatory axis. Moreover, we constructed a signature based on UPS-associated genes to predict the overall survival of CRC patients. Our research provides a novel insight view of the UPS and cell cycle system in CRC.https://www.frontiersin.org/articles/10.3389/fcell.2021.653528/fullUb–proteasome systemcell cyclesignaturecolorectal cancerbioinformatic |
| spellingShingle | Zhiyuan Zhang Jingwen Chen Wentao Tang Qingyang Feng Jianmin Xu Li Ren Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer Frontiers in Cell and Developmental Biology Ub–proteasome system cell cycle signature colorectal cancer bioinformatic |
| title | Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer |
| title_full | Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer |
| title_fullStr | Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer |
| title_full_unstemmed | Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer |
| title_short | Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer |
| title_sort | comprehensive analysis reveals the potential regulatory mechanism between ub proteasome system and cell cycle in colorectal cancer |
| topic | Ub–proteasome system cell cycle signature colorectal cancer bioinformatic |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.653528/full |
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