Virological Markers in Epstein–Barr Virus-Associated Diseases
Epstein–Barr virus (EBV) is an oncogenic virus infecting more than 95% of the world’s population. After primary infection—responsible for infectious mononucleosis in young adults—the virus persists lifelong in the infected host, especially in memory B cells. Viral persistence is usually without clin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/3/656 |
| _version_ | 1797608639884689408 |
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| author | Julien Lupo Aurélie Truffot Julien Andreani Mohammed Habib Olivier Epaulard Patrice Morand Raphaële Germi |
| author_facet | Julien Lupo Aurélie Truffot Julien Andreani Mohammed Habib Olivier Epaulard Patrice Morand Raphaële Germi |
| author_sort | Julien Lupo |
| collection | DOAJ |
| description | Epstein–Barr virus (EBV) is an oncogenic virus infecting more than 95% of the world’s population. After primary infection—responsible for infectious mononucleosis in young adults—the virus persists lifelong in the infected host, especially in memory B cells. Viral persistence is usually without clinical consequences, although it can lead to EBV-associated cancers such as lymphoma or carcinoma. Recent reports also suggest a link between EBV infection and multiple sclerosis. In the absence of vaccines, research efforts have focused on virological markers applicable in clinical practice for the management of patients with EBV-associated diseases. Nasopharyngeal carcinoma is an EBV-associated malignancy for which serological and molecular markers are widely used in clinical practice. Measuring blood EBV DNA load is additionally, useful for preventing lymphoproliferative disorders in transplant patients, with this marker also being explored in various other EBV-associated lymphomas. New technologies based on next-generation sequencing offer the opportunity to explore other biomarkers such as the EBV DNA methylome, strain diversity, or viral miRNA. Here, we review the clinical utility of different virological markers in EBV-associated diseases. Indeed, evaluating existing or new markers in EBV-associated malignancies or immune-mediated inflammatory diseases triggered by EBV infection continues to be a challenge. |
| first_indexed | 2024-03-11T05:47:24Z |
| format | Article |
| id | doaj.art-a8b538d8894f4e5f9287c053bd5a08e0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T05:47:24Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a8b538d8894f4e5f9287c053bd5a08e02023-11-17T14:22:29ZengMDPI AGViruses1999-49152023-02-0115365610.3390/v15030656Virological Markers in Epstein–Barr Virus-Associated DiseasesJulien Lupo0Aurélie Truffot1Julien Andreani2Mohammed Habib3Olivier Epaulard4Patrice Morand5Raphaële Germi6Institut de Biologie Structurale, Université Grenoble Alpes, UMR 5075 CEA/CNRS/UGA, 71 Avenue des Martyrs, 38000 Grenoble, FranceInstitut de Biologie Structurale, Université Grenoble Alpes, UMR 5075 CEA/CNRS/UGA, 71 Avenue des Martyrs, 38000 Grenoble, FranceInstitut de Biologie Structurale, Université Grenoble Alpes, UMR 5075 CEA/CNRS/UGA, 71 Avenue des Martyrs, 38000 Grenoble, FranceInstitut de Biologie Structurale, Université Grenoble Alpes, UMR 5075 CEA/CNRS/UGA, 71 Avenue des Martyrs, 38000 Grenoble, FranceInstitut de Biologie Structurale, Université Grenoble Alpes, UMR 5075 CEA/CNRS/UGA, 71 Avenue des Martyrs, 38000 Grenoble, FranceInstitut de Biologie Structurale, Université Grenoble Alpes, UMR 5075 CEA/CNRS/UGA, 71 Avenue des Martyrs, 38000 Grenoble, FranceInstitut de Biologie Structurale, Université Grenoble Alpes, UMR 5075 CEA/CNRS/UGA, 71 Avenue des Martyrs, 38000 Grenoble, FranceEpstein–Barr virus (EBV) is an oncogenic virus infecting more than 95% of the world’s population. After primary infection—responsible for infectious mononucleosis in young adults—the virus persists lifelong in the infected host, especially in memory B cells. Viral persistence is usually without clinical consequences, although it can lead to EBV-associated cancers such as lymphoma or carcinoma. Recent reports also suggest a link between EBV infection and multiple sclerosis. In the absence of vaccines, research efforts have focused on virological markers applicable in clinical practice for the management of patients with EBV-associated diseases. Nasopharyngeal carcinoma is an EBV-associated malignancy for which serological and molecular markers are widely used in clinical practice. Measuring blood EBV DNA load is additionally, useful for preventing lymphoproliferative disorders in transplant patients, with this marker also being explored in various other EBV-associated lymphomas. New technologies based on next-generation sequencing offer the opportunity to explore other biomarkers such as the EBV DNA methylome, strain diversity, or viral miRNA. Here, we review the clinical utility of different virological markers in EBV-associated diseases. Indeed, evaluating existing or new markers in EBV-associated malignancies or immune-mediated inflammatory diseases triggered by EBV infection continues to be a challenge.https://www.mdpi.com/1999-4915/15/3/656Epstein–Barr virusserologyEBV DNAbiomarkersinfectious mononucleosislymphoma |
| spellingShingle | Julien Lupo Aurélie Truffot Julien Andreani Mohammed Habib Olivier Epaulard Patrice Morand Raphaële Germi Virological Markers in Epstein–Barr Virus-Associated Diseases Viruses Epstein–Barr virus serology EBV DNA biomarkers infectious mononucleosis lymphoma |
| title | Virological Markers in Epstein–Barr Virus-Associated Diseases |
| title_full | Virological Markers in Epstein–Barr Virus-Associated Diseases |
| title_fullStr | Virological Markers in Epstein–Barr Virus-Associated Diseases |
| title_full_unstemmed | Virological Markers in Epstein–Barr Virus-Associated Diseases |
| title_short | Virological Markers in Epstein–Barr Virus-Associated Diseases |
| title_sort | virological markers in epstein barr virus associated diseases |
| topic | Epstein–Barr virus serology EBV DNA biomarkers infectious mononucleosis lymphoma |
| url | https://www.mdpi.com/1999-4915/15/3/656 |
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