COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIA
Prospective examination of 21 pregnant women with chronic arterial hypertension, 81 pregnant women with preeclamsia of various degree of severity and 25 healthy pregnant women was conducted. Comparative assessment of neurospecific proteins NSE and GFAP in blood serum and also immunomorphologic inves...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-09-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/335 |
| _version_ | 1797884141479395328 |
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| author | I. S. Sidorova A. L. Unanayan N. A. Nikitina A. A. Rzaeva V. V. Kinyakin |
| author_facet | I. S. Sidorova A. L. Unanayan N. A. Nikitina A. A. Rzaeva V. V. Kinyakin |
| author_sort | I. S. Sidorova |
| collection | DOAJ |
| description | Prospective examination of 21 pregnant women with chronic arterial hypertension, 81 pregnant women with preeclamsia of various degree of severity and 25 healthy pregnant women was conducted. Comparative assessment of neurospecific proteins NSE and GFAP in blood serum and also immunomorphologic investigation of placenta tissue in women with hypertension and preeclampsia was demonstrated. Compared to blood serum and placenta tissue taken from women with preeclamsia, in women with arterial hypertension neurospecific proteins with high immunogenic activity that may lead to development of severe immunopathologic process were not discovered. Pregnancy prolongation with adequate hypotensive therapy and good blood pressure control is possible. Development of preeclampsia is associated with sudden increase in neurospecific protein levels, severe immune endothelial damage of macro-and microcirculation vessels; To stop the progression of this process is possible only with delivery, that is indicated in case of eclampsia, severe preeclampsia and in its moderate forms ineffective treatment. |
| first_indexed | 2024-04-10T04:02:55Z |
| format | Article |
| id | doaj.art-a8b5ff09125f47cc993a7ca2252cfdd2 |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:02:55Z |
| publishDate | 2016-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-a8b5ff09125f47cc993a7ca2252cfdd22023-03-13T07:09:48ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-09-01642932333COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIAI. S. Sidorova0A. L. Unanayan1N. A. Nikitina2A. A. Rzaeva3V. V. Kinyakin4GBOU VPO «First MSMU named after I.M. Sechenov» Ministry of Health and Social Development of Russia, MoscowGBOU VPO «First MSMU named after I.M. Sechenov» Ministry of Health and Social Development of Russia, MoscowGBOU VPO «First MSMU named after I.M. Sechenov» Ministry of Health and Social Development of Russia, MoscowGBOU VPO «First MSMU named after I.M. Sechenov» Ministry of Health and Social Development of Russia, MoscowGBOU VPO «First MSMU named after I.M. Sechenov» Ministry of Health and Social Development of Russia, MoscowProspective examination of 21 pregnant women with chronic arterial hypertension, 81 pregnant women with preeclamsia of various degree of severity and 25 healthy pregnant women was conducted. Comparative assessment of neurospecific proteins NSE and GFAP in blood serum and also immunomorphologic investigation of placenta tissue in women with hypertension and preeclampsia was demonstrated. Compared to blood serum and placenta tissue taken from women with preeclamsia, in women with arterial hypertension neurospecific proteins with high immunogenic activity that may lead to development of severe immunopathologic process were not discovered. Pregnancy prolongation with adequate hypotensive therapy and good blood pressure control is possible. Development of preeclampsia is associated with sudden increase in neurospecific protein levels, severe immune endothelial damage of macro-and microcirculation vessels; To stop the progression of this process is possible only with delivery, that is indicated in case of eclampsia, severe preeclampsia and in its moderate forms ineffective treatment.https://www.gynecology.su/jour/article/view/335preeclampsiaarterial hypertensionendotheliosisneurospecific proteins |
| spellingShingle | I. S. Sidorova A. L. Unanayan N. A. Nikitina A. A. Rzaeva V. V. Kinyakin COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIA Акушерство, гинекология и репродукция preeclampsia arterial hypertension endotheliosis neurospecific proteins |
| title | COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIA |
| title_full | COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIA |
| title_fullStr | COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIA |
| title_full_unstemmed | COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIA |
| title_short | COMPARATIVE ASSESSMENT OF MOLECULAR AND IMMUNOHYSTOCHEMICAL MARKERS OF IMMUNE ENDOTHELIAL DAMAGE IN PREGNANTS WITH ARTERIAL HYPERTENSION AND PREECLAMSIA |
| title_sort | comparative assessment of molecular and immunohystochemical markers of immune endothelial damage in pregnants with arterial hypertension and preeclamsia |
| topic | preeclampsia arterial hypertension endotheliosis neurospecific proteins |
| url | https://www.gynecology.su/jour/article/view/335 |
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