Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness
Abstract Background A plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequently reported, the number of patients with hyperglutaminemia has so far be...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Critical Care |
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| Online Access: | https://doi.org/10.1186/s13054-021-03640-3 |
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| author | Marie Smedberg Johan Helleberg Åke Norberg Inga Tjäder Olav Rooyackers Jan Wernerman |
| author_facet | Marie Smedberg Johan Helleberg Åke Norberg Inga Tjäder Olav Rooyackers Jan Wernerman |
| author_sort | Marie Smedberg |
| collection | DOAJ |
| description | Abstract Background A plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequently reported, the number of patients with hyperglutaminemia has so far been quite few. Therefore, the association between hyperglutaminemia and mortality outcomes was studied in a prospective, observational study. Patients and methods Consecutive admissions to a mixed general ICU were eligible. Exclusion criteria were < 18 years of age, readmissions, no informed consent, or a ‘do not resuscitate’ order at admission. A blood sample was saved within one hour from admission to be analysed by high-pressure liquid chromatography for glutamine concentration. Conventional risk scoring (Simplified Acute Physiology Score and Sequential Organ Failure Assessment) at admission, and mortality outcomes were recorded for all included patients. Results Out of 269 included patients, 26 were hyperglutaminemic (≥ 930 µmol/L) at admission. The six-month mortality rate for this subgroup was 46%, compared to 18% for patients with a plasma glutamine concentration < 930 µmol/L (P = 0.002). A regression analysis showed that hyperglutaminemia was an independent mortality predictor that added prediction value to conventional admission risk scoring and age. Conclusion Hyperglutaminemia in critical illness at ICU admission was an independent mortality predictor, often but not always, associated with an acute liver condition. The mechanism behind a plasma glutamine concentration outside normal range, as well as the prognostic value of repeated measurements of plasma glutamine during ICU stay, remains to be investigated. |
| first_indexed | 2024-12-16T17:54:21Z |
| format | Article |
| id | doaj.art-a8b69ef7c4bd4b1580044011a63d172e |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-16T17:54:21Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-a8b69ef7c4bd4b1580044011a63d172e2022-12-21T22:22:13ZengBMCCritical Care1364-85352021-07-012511910.1186/s13054-021-03640-3Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illnessMarie Smedberg0Johan Helleberg1Åke Norberg2Inga Tjäder3Olav Rooyackers4Jan Wernerman5Department of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge StockholmDepartment of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge StockholmDepartment of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge StockholmDepartment of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge StockholmDepartment of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge StockholmDepartment of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge StockholmAbstract Background A plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequently reported, the number of patients with hyperglutaminemia has so far been quite few. Therefore, the association between hyperglutaminemia and mortality outcomes was studied in a prospective, observational study. Patients and methods Consecutive admissions to a mixed general ICU were eligible. Exclusion criteria were < 18 years of age, readmissions, no informed consent, or a ‘do not resuscitate’ order at admission. A blood sample was saved within one hour from admission to be analysed by high-pressure liquid chromatography for glutamine concentration. Conventional risk scoring (Simplified Acute Physiology Score and Sequential Organ Failure Assessment) at admission, and mortality outcomes were recorded for all included patients. Results Out of 269 included patients, 26 were hyperglutaminemic (≥ 930 µmol/L) at admission. The six-month mortality rate for this subgroup was 46%, compared to 18% for patients with a plasma glutamine concentration < 930 µmol/L (P = 0.002). A regression analysis showed that hyperglutaminemia was an independent mortality predictor that added prediction value to conventional admission risk scoring and age. Conclusion Hyperglutaminemia in critical illness at ICU admission was an independent mortality predictor, often but not always, associated with an acute liver condition. The mechanism behind a plasma glutamine concentration outside normal range, as well as the prognostic value of repeated measurements of plasma glutamine during ICU stay, remains to be investigated.https://doi.org/10.1186/s13054-021-03640-3Plasma glutamineCritical illnessHyperglutaminemiaMortalityLiver failure |
| spellingShingle | Marie Smedberg Johan Helleberg Åke Norberg Inga Tjäder Olav Rooyackers Jan Wernerman Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness Critical Care Plasma glutamine Critical illness Hyperglutaminemia Mortality Liver failure |
| title | Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness |
| title_full | Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness |
| title_fullStr | Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness |
| title_full_unstemmed | Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness |
| title_short | Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness |
| title_sort | plasma glutamine status at intensive care unit admission an independent risk factor for mortality in critical illness |
| topic | Plasma glutamine Critical illness Hyperglutaminemia Mortality Liver failure |
| url | https://doi.org/10.1186/s13054-021-03640-3 |
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