Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery
As a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, traditional Chinese medicine (TCM) has attracted global attention in the life science field. TCM provides extensive natural resources for medicinal compounds, and these resources are gene...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00743/full |
| _version_ | 1811324638199808000 |
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| author | Wenjuan Zhang Wenjuan Zhang Wenjuan Zhang Ying Huai Ying Huai Ying Huai Zhiping Miao Zhiping Miao Zhiping Miao Airong Qian Airong Qian Airong Qian Yonghua Wang |
| author_facet | Wenjuan Zhang Wenjuan Zhang Wenjuan Zhang Ying Huai Ying Huai Ying Huai Zhiping Miao Zhiping Miao Zhiping Miao Airong Qian Airong Qian Airong Qian Yonghua Wang |
| author_sort | Wenjuan Zhang |
| collection | DOAJ |
| description | As a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, traditional Chinese medicine (TCM) has attracted global attention in the life science field. TCM provides extensive natural resources for medicinal compounds, and these resources are generally regarded as effective and safe for use in drug discovery. However, owing to the complexity of compounds and their related multiple targets of TCM, it remains difficult to dissect the mechanisms of action of herbal medicines at a holistic level. To solve the issue, in the review, we proposed a novel approach of systems pharmacology to identify the bioactive compounds, predict their related targets, and illustrate the molecular mechanisms of action of TCM. With a predominant focus on the mechanisms of actions of TCM, we also highlighted the application of the systems pharmacology approach for the prediction of drug combination and dynamic analysis, the synergistic effects of TCMs, formula dissection, and theory analysis. In summary, the systems pharmacology method contributes to understand the complex interactions among biological systems, drugs, and complex diseases from a network perspective. Consequently, systems pharmacology provides a novel approach to promote drug discovery in a precise manner and a systems level, thus facilitating the modernization of TCM. |
| first_indexed | 2024-04-13T14:17:53Z |
| format | Article |
| id | doaj.art-a8b920ab7a1c4f97b35c2987214cdd17 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T14:17:53Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a8b920ab7a1c4f97b35c2987214cdd172022-12-22T02:43:35ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-07-011010.3389/fphar.2019.00743455251Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug DiscoveryWenjuan Zhang0Wenjuan Zhang1Wenjuan Zhang2Ying Huai3Ying Huai4Ying Huai5Zhiping Miao6Zhiping Miao7Zhiping Miao8Airong Qian9Airong Qian10Airong Qian11Yonghua Wang12Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaNPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaNPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaNPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaNPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaLab of Systems Pharmacology, College of Life Sciences, Northwest University, Xi’an, ChinaAs a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, traditional Chinese medicine (TCM) has attracted global attention in the life science field. TCM provides extensive natural resources for medicinal compounds, and these resources are generally regarded as effective and safe for use in drug discovery. However, owing to the complexity of compounds and their related multiple targets of TCM, it remains difficult to dissect the mechanisms of action of herbal medicines at a holistic level. To solve the issue, in the review, we proposed a novel approach of systems pharmacology to identify the bioactive compounds, predict their related targets, and illustrate the molecular mechanisms of action of TCM. With a predominant focus on the mechanisms of actions of TCM, we also highlighted the application of the systems pharmacology approach for the prediction of drug combination and dynamic analysis, the synergistic effects of TCMs, formula dissection, and theory analysis. In summary, the systems pharmacology method contributes to understand the complex interactions among biological systems, drugs, and complex diseases from a network perspective. Consequently, systems pharmacology provides a novel approach to promote drug discovery in a precise manner and a systems level, thus facilitating the modernization of TCM.https://www.frontiersin.org/article/10.3389/fphar.2019.00743/fullbioactive compoundstarget identificationsystems pharmacologysynergistic effectdrug discovery |
| spellingShingle | Wenjuan Zhang Wenjuan Zhang Wenjuan Zhang Ying Huai Ying Huai Ying Huai Zhiping Miao Zhiping Miao Zhiping Miao Airong Qian Airong Qian Airong Qian Yonghua Wang Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery Frontiers in Pharmacology bioactive compounds target identification systems pharmacology synergistic effect drug discovery |
| title | Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery |
| title_full | Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery |
| title_fullStr | Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery |
| title_full_unstemmed | Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery |
| title_short | Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery |
| title_sort | systems pharmacology for investigation of the mechanisms of action of traditional chinese medicine in drug discovery |
| topic | bioactive compounds target identification systems pharmacology synergistic effect drug discovery |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00743/full |
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