Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients
Abstract Background Daily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective of children with Morbus Hodgkin. Methods Eleven radiotherapy treatment...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-018-1109-8 |
| _version_ | 1818543069834772480 |
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| author | Yvonne Dzierma Katharina Mikulla Patrick Richter Katharina Bell Patrick Melchior Frank Nuesken Christian Rübe |
| author_facet | Yvonne Dzierma Katharina Mikulla Patrick Richter Katharina Bell Patrick Melchior Frank Nuesken Christian Rübe |
| author_sort | Yvonne Dzierma |
| collection | DOAJ |
| description | Abstract Background Daily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective of children with Morbus Hodgkin. Methods Eleven radiotherapy treatment plans from pediatric patients with Hodgkin’s lymphoma were retrospectively analyzed, including imaging dose from scenarios using different energies (kV/MV) and planar/cone-beam computed tomography (CBCT) techniques. In addition to assessing the effect of imaging dose on organs at risk, the excess average risk (EAR) for developing a secondary carcinoma of the lung or breast was modelled. Results Although the variability between the patients is relatively large due to the different target volumes, the additional EAR due to imaging can be consistently determined. For daily 6MV CBCT, the EAR for developing a secondary cancer at age 50 is over 3 cases per 104 PY (patient-years) for the female breast and 0.7–0.8 per 104 PY for the lungs. This can be decreased by using only planar images (< 1 per 104 PY for the breast and 0.1 for the lungs). Similar values are achieved by daily 360° kV CBCT (0.44–0.57 per 104 PY for the breast and 0.08 per 104 PY for the lungs), which is again reduced for daily 200° kV CBCT (0.02 per 104 PY for the lungs and 0.07–0.08 per 104 PY for the breast). These values increase if an older attained age is considered (e.g., for 70 years, by a factor of four for the lungs). Conclusions Daily imaging can be performed with an additional secondary cancer risk of less than 1 per 104 PY if kV CBCT is applied. If MV modalities must be chosen, a similar EAR can be achieved with planar images. A further reduction in risk is possible if the imaging geometry allows for sparing of the breast by a partial rotation underneath the patient. |
| first_indexed | 2024-12-11T22:30:28Z |
| format | Article |
| id | doaj.art-a8b99a22dd32480983cff5f580d43200 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-11T22:30:28Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-a8b99a22dd32480983cff5f580d432002022-12-22T00:48:09ZengBMCRadiation Oncology1748-717X2018-09-0113111410.1186/s13014-018-1109-8Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patientsYvonne Dzierma0Katharina Mikulla1Patrick Richter2Katharina Bell3Patrick Melchior4Frank Nuesken5Christian Rübe6Department of Radiotherapy and Radiation Oncology, Saarland University Medical CentreDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical CentreDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical CentreDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical CentreDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical CentreDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical CentreDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical CentreAbstract Background Daily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective of children with Morbus Hodgkin. Methods Eleven radiotherapy treatment plans from pediatric patients with Hodgkin’s lymphoma were retrospectively analyzed, including imaging dose from scenarios using different energies (kV/MV) and planar/cone-beam computed tomography (CBCT) techniques. In addition to assessing the effect of imaging dose on organs at risk, the excess average risk (EAR) for developing a secondary carcinoma of the lung or breast was modelled. Results Although the variability between the patients is relatively large due to the different target volumes, the additional EAR due to imaging can be consistently determined. For daily 6MV CBCT, the EAR for developing a secondary cancer at age 50 is over 3 cases per 104 PY (patient-years) for the female breast and 0.7–0.8 per 104 PY for the lungs. This can be decreased by using only planar images (< 1 per 104 PY for the breast and 0.1 for the lungs). Similar values are achieved by daily 360° kV CBCT (0.44–0.57 per 104 PY for the breast and 0.08 per 104 PY for the lungs), which is again reduced for daily 200° kV CBCT (0.02 per 104 PY for the lungs and 0.07–0.08 per 104 PY for the breast). These values increase if an older attained age is considered (e.g., for 70 years, by a factor of four for the lungs). Conclusions Daily imaging can be performed with an additional secondary cancer risk of less than 1 per 104 PY if kV CBCT is applied. If MV modalities must be chosen, a similar EAR can be achieved with planar images. A further reduction in risk is possible if the imaging geometry allows for sparing of the breast by a partial rotation underneath the patient.http://link.springer.com/article/10.1186/s13014-018-1109-8Secondary cancer riskRadiotherapy for Hodgkin lymphomaImage-guided radiotherapyImaging dose in pediatric patients |
| spellingShingle | Yvonne Dzierma Katharina Mikulla Patrick Richter Katharina Bell Patrick Melchior Frank Nuesken Christian Rübe Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients Radiation Oncology Secondary cancer risk Radiotherapy for Hodgkin lymphoma Image-guided radiotherapy Imaging dose in pediatric patients |
| title | Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients |
| title_full | Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients |
| title_fullStr | Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients |
| title_full_unstemmed | Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients |
| title_short | Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients |
| title_sort | imaging dose and secondary cancer risk in image guided radiotherapy of pediatric patients |
| topic | Secondary cancer risk Radiotherapy for Hodgkin lymphoma Image-guided radiotherapy Imaging dose in pediatric patients |
| url | http://link.springer.com/article/10.1186/s13014-018-1109-8 |
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