Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies
Abstract Background Several epidemiological studies have investigated the association between dietary fat intake and cardiovascular disease. However, dietary recommendations based on systematic review and meta-analysis might be more credible. Methods and results Pubmed, Embase and Cochrane library w...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-019-1035-2 |
| _version_ | 1828416174060208128 |
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| author | Yongjian Zhu Yacong Bo Yanhua Liu |
| author_facet | Yongjian Zhu Yacong Bo Yanhua Liu |
| author_sort | Yongjian Zhu |
| collection | DOAJ |
| description | Abstract Background Several epidemiological studies have investigated the association between dietary fat intake and cardiovascular disease. However, dietary recommendations based on systematic review and meta-analysis might be more credible. Methods and results Pubmed, Embase and Cochrane library were searched up to July 1st 2018 for cohort studies reporting associations of dietary fat intake and risk of CVDs. By comparing the highest vs. the lowest categories of fat or fatty acids intake, we found that higher dietary trans fatty acids (TFA) intake was associated with increased risk of CVDs [RR:1.14(1.08–1.21)]. However, no association was observed between total fat, monounsaturated fatty acids (MUFA), saturated fatty acids (SFA), and polyunsaturated fatty acids (PUFA), and risk of CVDs. Subgroup analysis found a cardio-protective effect of PUFA in the studies that has been followed up more than 10 years [0.95(0.91–0.99), I 2 = 62.4%]. Dose-response analysis suggested that the risk of CVDs increased 16% [1.16 (1.07–1.25), Plinearity = 0.033] for an increment of 2% energy/day of TFA intake. Conclusions This current meta-analysis of cohort studies suggested that total fat, SFA, MUFA, and PUFA intake were not associated with the risk of cardiovascular disease. However, we found that higher TFA intake is associated with greater risk of CVDs in a dose-response fashion. Furthermore, the subgroup analysis found a cardio-protective effect of PUFA in studies followed up for more than 10 years. |
| first_indexed | 2024-12-10T13:59:48Z |
| format | Article |
| id | doaj.art-a8b99af288ed40c5a21c7e91a9206146 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-10T13:59:48Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-a8b99af288ed40c5a21c7e91a92061462022-12-22T01:45:51ZengBMCLipids in Health and Disease1476-511X2019-04-0118111410.1186/s12944-019-1035-2Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studiesYongjian Zhu0Yacong Bo1Yanhua Liu2Department of Cardiology, The first affiliated hospital of Zhengzhou UniversityDepartment of Nutrition, The first affiliated hospital of Zhengzhou UniversityDepartment of Nutrition, The first affiliated hospital of Zhengzhou UniversityAbstract Background Several epidemiological studies have investigated the association between dietary fat intake and cardiovascular disease. However, dietary recommendations based on systematic review and meta-analysis might be more credible. Methods and results Pubmed, Embase and Cochrane library were searched up to July 1st 2018 for cohort studies reporting associations of dietary fat intake and risk of CVDs. By comparing the highest vs. the lowest categories of fat or fatty acids intake, we found that higher dietary trans fatty acids (TFA) intake was associated with increased risk of CVDs [RR:1.14(1.08–1.21)]. However, no association was observed between total fat, monounsaturated fatty acids (MUFA), saturated fatty acids (SFA), and polyunsaturated fatty acids (PUFA), and risk of CVDs. Subgroup analysis found a cardio-protective effect of PUFA in the studies that has been followed up more than 10 years [0.95(0.91–0.99), I 2 = 62.4%]. Dose-response analysis suggested that the risk of CVDs increased 16% [1.16 (1.07–1.25), Plinearity = 0.033] for an increment of 2% energy/day of TFA intake. Conclusions This current meta-analysis of cohort studies suggested that total fat, SFA, MUFA, and PUFA intake were not associated with the risk of cardiovascular disease. However, we found that higher TFA intake is associated with greater risk of CVDs in a dose-response fashion. Furthermore, the subgroup analysis found a cardio-protective effect of PUFA in studies followed up for more than 10 years.http://link.springer.com/article/10.1186/s12944-019-1035-2FatFatty acidsCardiovascular diseaseMeta-analysisDose-response |
| spellingShingle | Yongjian Zhu Yacong Bo Yanhua Liu Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies Lipids in Health and Disease Fat Fatty acids Cardiovascular disease Meta-analysis Dose-response |
| title | Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies |
| title_full | Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies |
| title_fullStr | Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies |
| title_full_unstemmed | Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies |
| title_short | Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies |
| title_sort | dietary total fat fatty acids intake and risk of cardiovascular disease a dose response meta analysis of cohort studies |
| topic | Fat Fatty acids Cardiovascular disease Meta-analysis Dose-response |
| url | http://link.springer.com/article/10.1186/s12944-019-1035-2 |
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