Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral d...
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/6/1566 |
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| author | Hiroyuki Inose Tsuyoshi Kato Shoichi Ichimura Hiroaki Nakamura Masatoshi Hoshino Shinji Takahashi Daisuke Togawa Toru Hirano Yasuaki Tokuhashi Tetsuro Ohba Hirotaka Haro Takashi Tsuji Kimiaki Sato Yutaka Sasao Masahiko Takahata Koji Otani Suketaka Momoshima Takashi Hirai Toshitaka Yoshii Atsushi Okawa |
| author_facet | Hiroyuki Inose Tsuyoshi Kato Shoichi Ichimura Hiroaki Nakamura Masatoshi Hoshino Shinji Takahashi Daisuke Togawa Toru Hirano Yasuaki Tokuhashi Tetsuro Ohba Hirotaka Haro Takashi Tsuji Kimiaki Sato Yutaka Sasao Masahiko Takahata Koji Otani Suketaka Momoshima Takashi Hirai Toshitaka Yoshii Atsushi Okawa |
| author_sort | Hiroyuki Inose |
| collection | DOAJ |
| description | Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable. |
| first_indexed | 2024-03-09T19:37:46Z |
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| id | doaj.art-a8bc200ec14b4fc8b4d8bd43dd276d4f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T19:37:46Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a8bc200ec14b4fc8b4d8bd43dd276d4f2023-11-24T01:48:26ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01116156610.3390/jcm11061566Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral FracturesHiroyuki Inose0Tsuyoshi Kato1Shoichi Ichimura2Hiroaki Nakamura3Masatoshi Hoshino4Shinji Takahashi5Daisuke Togawa6Toru Hirano7Yasuaki Tokuhashi8Tetsuro Ohba9Hirotaka Haro10Takashi Tsuji11Kimiaki Sato12Yutaka Sasao13Masahiko Takahata14Koji Otani15Suketaka Momoshima16Takashi Hirai17Toshitaka Yoshii18Atsushi Okawa19Department of Orthopaedic and Trauma Research, Graduate School, Tokyo Medical and Dental University, Tokyo 108-0075, JapanDepartment of Orthopaedics, Ome Municipal General Hospital, Tokyo 198-0042, JapanDepartment of Orthopaedics, Kyorin University, Tokyo 181-8611, JapanDepartment of Orthopedic Surgery, Graduate School of Medicine, Osaka City University, Osaka 545-8585, JapanDepartment of Orthopedic Surgery, Graduate School of Medicine, Osaka City University, Osaka 545-8585, JapanDepartment of Orthopedic Surgery, Graduate School of Medicine, Osaka City University, Osaka 545-8585, JapanDepartment of Orthopaedic Surgery, Hamamatsu University of Medicine, Shizuoka 431-3192, JapanDepartment of Orthopedic Surgery, Niigata University Medical and Dental Hospital, Niigata 951-8520, JapanDepartment of Orthopaedic Surgery, Nihon University, Tokyo 173-8610, JapanDepartment of Orthopaedic Surgery, University of Yamanashi, Yamanashi 409-3898, JapanDepartment of Orthopaedic Surgery, University of Yamanashi, Yamanashi 409-3898, JapanDepartment of Orthopaedic Surgery, Kitasato University Kitasato Institute Hospital, Tokyo 108-8642, JapanDepartment of Orthopaedic Surgery, Kurume University School of Medicine, Kurume University, Fukuoka 830-0011, JapanDepartment of Orthopaedic Surgery, Graduate School, School of Medicine, St. Marianna University, Kanagawa 216-8511, JapanDepartment of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Hokkaido 060-8638, JapanDepartment of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Diagnostic Radiology, Center for Preventive Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 108-0075, JapanDepartment of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 108-0075, JapanDepartment of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 108-0075, JapanAlthough osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable.https://www.mdpi.com/2077-0383/11/6/1566residual low back painosteoporotic vertebral fracturesnonunionvertebral deformitythoracolumbar alignmentradiographic evaluation |
| spellingShingle | Hiroyuki Inose Tsuyoshi Kato Shoichi Ichimura Hiroaki Nakamura Masatoshi Hoshino Shinji Takahashi Daisuke Togawa Toru Hirano Yasuaki Tokuhashi Tetsuro Ohba Hirotaka Haro Takashi Tsuji Kimiaki Sato Yutaka Sasao Masahiko Takahata Koji Otani Suketaka Momoshima Takashi Hirai Toshitaka Yoshii Atsushi Okawa Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures Journal of Clinical Medicine residual low back pain osteoporotic vertebral fractures nonunion vertebral deformity thoracolumbar alignment radiographic evaluation |
| title | Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures |
| title_full | Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures |
| title_fullStr | Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures |
| title_full_unstemmed | Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures |
| title_short | Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures |
| title_sort | factors contributing to residual low back pain after osteoporotic vertebral fractures |
| topic | residual low back pain osteoporotic vertebral fractures nonunion vertebral deformity thoracolumbar alignment radiographic evaluation |
| url | https://www.mdpi.com/2077-0383/11/6/1566 |
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