Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease

Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease

Serotonin (5-hydroxytryptophan) is a hormone that regulates emotions in the central nervous system. However, serotonin in the peripheral system is associated with obesity and fatty liver disease. Because serotonin cannot cross the blood-brain barrier (BBB), we focused on identifying new tryptophan h...

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Bibliographic Details
Main Authors: Suvarna H. Pagire, Haushabhau S. Pagire, Kun-Young Park, Eun Jung Bae, Kwang-eun Kim, Minhee Kim, Jihyeon Yoon, Saravanan Parameswaran, Jun-Ho Choi, Sungmi Park, Jae-Han Jeon, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jae Myoung Suh, Jin Hee Ahn
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
tryptophan hydroxylase inhibitor
obesity
fatty liver
treatment
Online Access:https://www.mdpi.com/1420-3049/27/11/3417

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