Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management

Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management

Partner and localizer of BRCA2 (PALB2) is vital for homologous recombination (HR) repair in response to DNA double-strand breaks (DSBs). PALB2 functions as a tumor suppressor and participates in the maintenance of genome integrity. In this review, we summarize the current knowledge of the biological...

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Bibliographic Details
Main Authors: Shijie Wu, Jiaojiao Zhou, Kun Zhang, Huihui Chen, Meng Luo, Yuexin Lu, Yuting Sun, Yiding Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
PALB2
homologous recombination
breast cancer
precision medicine
pathogenic variants
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00301/full

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