Therapeutic Targeting of Neutrophil Extracellular Traps Improves Primary and Secondary Intention Wound Healing in Mice

Therapeutic Targeting of Neutrophil Extracellular Traps Improves Primary and Secondary Intention Wound Healing in Mice

BackgroundNeutrophils are the first responders in wound healing after injury that mediate pro- and anti-inflammatory activities i.a. through the formation of extracellular traps (NETs). However, excessive NETs presence in wound tissue can cause local hyperinflammation and -coagulation resulting in d...

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Bibliographic Details
Main Authors: Annika Heuer, Carolin Stiel, Julia Elrod, Ingo Königs, Deirdre Vincent, Patrick Schlegel, Magdalena Trochimiuk, Birgit Appl, Konrad Reinshagen, Laia Pagerols Raluy, Michael Boettcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
scars
burns
wound healing
neutrophil extracellular traps
DNases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.614347/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.614347/full

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