A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi
We report the molecular characterization of a novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Steady-state level of transcripts of this sequence family appeared to be developmentally regulated, since only in the replicative fo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2003-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100016 |
| _version_ | 1797757275336605696 |
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| author | Newton Valério Verbisck Márcia Regina Machado dos Santos David M Engman Miguel Angel Chiurillo José Luis Ramirez Jorge Enrique Araya Renato Arruda Mortara José Franco da Silveira |
| author_facet | Newton Valério Verbisck Márcia Regina Machado dos Santos David M Engman Miguel Angel Chiurillo José Luis Ramirez Jorge Enrique Araya Renato Arruda Mortara José Franco da Silveira |
| author_sort | Newton Valério Verbisck |
| collection | DOAJ |
| description | We report the molecular characterization of a novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Steady-state level of transcripts of this sequence family appeared to be developmentally regulated, since only in the replicative forms the parasite showed expression of related sequences with a major band around 3 kb. The presence of frame shifts or premature stop codons predicts that transcripts are not translated. The sequence family also contains truncated forms of retrotransposons elements that may become potential hot spots for retroelement insertion. Sequences homologous to this family are interspersed at many chromosomes including the subtelomeric regions. |
| first_indexed | 2024-03-12T18:13:33Z |
| format | Article |
| id | doaj.art-a8c1ce22a9054e1584ed4e889badd9ca |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:13:33Z |
| publishDate | 2003-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-a8c1ce22a9054e1584ed4e889badd9ca2023-08-02T09:14:11ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602003-01-0198112913310.1590/S0074-02762003000100016A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruziNewton Valério VerbisckMárcia Regina Machado dos SantosDavid M EngmanMiguel Angel ChiurilloJosé Luis RamirezJorge Enrique ArayaRenato Arruda MortaraJosé Franco da SilveiraWe report the molecular characterization of a novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Steady-state level of transcripts of this sequence family appeared to be developmentally regulated, since only in the replicative forms the parasite showed expression of related sequences with a major band around 3 kb. The presence of frame shifts or premature stop codons predicts that transcripts are not translated. The sequence family also contains truncated forms of retrotransposons elements that may become potential hot spots for retroelement insertion. Sequences homologous to this family are interspersed at many chromosomes including the subtelomeric regions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100016Trypanosoma cruziinterspersed repetitive DNAtranscriptionretroelement insertionsubtelomeric region |
| spellingShingle | Newton Valério Verbisck Márcia Regina Machado dos Santos David M Engman Miguel Angel Chiurillo José Luis Ramirez Jorge Enrique Araya Renato Arruda Mortara José Franco da Silveira A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi Memorias do Instituto Oswaldo Cruz Trypanosoma cruzi interspersed repetitive DNA transcription retroelement insertion subtelomeric region |
| title | A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi |
| title_full | A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi |
| title_fullStr | A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi |
| title_full_unstemmed | A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi |
| title_short | A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi |
| title_sort | novel reiterated family of transcribed oligo a terminated interspersed dna elements in the genome of trypanosoma cruzi |
| topic | Trypanosoma cruzi interspersed repetitive DNA transcription retroelement insertion subtelomeric region |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100016 |
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