Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI
ObjectiveThis study aimed to explore the impact of the sperm DNA fragmentation index (DFI) on the clinical outcomes in women undergoing artificial insemination by husband intrauterine insemination (AIH-IUI).MethodsIn this retrospective study, the value of sperm DFI was detected by sperm chromatin st...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.987812/full |
| _version_ | 1797999342092550144 |
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| author | Chunhui Zhu Chunhui Zhu Shengmin Zhang Fang Chen Hong She Yun Ju Xidong Wen Yurong Ji Yu Pan Chunxia Yang Yan Sun Naijun Dong Kaifeng Liu Feng Li Tongmin Xue Hengmi Cui |
| author_facet | Chunhui Zhu Chunhui Zhu Shengmin Zhang Fang Chen Hong She Yun Ju Xidong Wen Yurong Ji Yu Pan Chunxia Yang Yan Sun Naijun Dong Kaifeng Liu Feng Li Tongmin Xue Hengmi Cui |
| author_sort | Chunhui Zhu |
| collection | DOAJ |
| description | ObjectiveThis study aimed to explore the impact of the sperm DNA fragmentation index (DFI) on the clinical outcomes in women undergoing artificial insemination by husband intrauterine insemination (AIH-IUI).MethodsIn this retrospective study, the value of sperm DFI was detected by sperm chromatin structure assay (SCSA) in a semen analysis collected before fertility treatment (basal DFI) in 1,500 IUI cycles at the infertility clinic of Northern Jiangsu People’s Hospital Reproductive Medicine Center from Jan 2016 to April 2021. Receiver operating characteristic (ROC) curves were used to calculate the cut-off value for the clinical outcomes of IUI, including the biochemical pregnancy rate, clinical pregnancy rate, delivery rate, and live birth rate, and multivariate logistic regression was conducted to analyse the risk factors for clinical outcomes after IUI.ResultIn 1,500 IUI cycles, the results showed that there were no statistically significant differences between the normal DFI group and the abnormal DFI group in biochemical pregnancy rate (14.41% vs. 11.3%, P = 0.386), clinical pregnancy rate (12.9% vs. 10.5%, P = 0.433), delivery rate (11.0% vs. 8.9%, P = 0.456), live birth rate (10.9% vs. 8.9%, P = 0.484) or pregnancy loss rate (14.6% vs. 15.4%, P = 1.000).ConclusionSperm DFI alone may have limited predictive power for IUI clinical outcomes. |
| first_indexed | 2024-04-11T11:03:14Z |
| format | Article |
| id | doaj.art-a8c2dfd78af840abb24a370ead4c7eff |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T11:03:14Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a8c2dfd78af840abb24a370ead4c7eff2022-12-22T04:28:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.987812987812Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUIChunhui Zhu0Chunhui Zhu1Shengmin Zhang2Fang Chen3Hong She4Yun Ju5Xidong Wen6Yurong Ji7Yu Pan8Chunxia Yang9Yan Sun10Naijun Dong11Kaifeng Liu12Feng Li13Tongmin Xue14Hengmi Cui15Department of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaInstitute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Reproductive Medicine Center, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, ChinaInstitute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaObjectiveThis study aimed to explore the impact of the sperm DNA fragmentation index (DFI) on the clinical outcomes in women undergoing artificial insemination by husband intrauterine insemination (AIH-IUI).MethodsIn this retrospective study, the value of sperm DFI was detected by sperm chromatin structure assay (SCSA) in a semen analysis collected before fertility treatment (basal DFI) in 1,500 IUI cycles at the infertility clinic of Northern Jiangsu People’s Hospital Reproductive Medicine Center from Jan 2016 to April 2021. Receiver operating characteristic (ROC) curves were used to calculate the cut-off value for the clinical outcomes of IUI, including the biochemical pregnancy rate, clinical pregnancy rate, delivery rate, and live birth rate, and multivariate logistic regression was conducted to analyse the risk factors for clinical outcomes after IUI.ResultIn 1,500 IUI cycles, the results showed that there were no statistically significant differences between the normal DFI group and the abnormal DFI group in biochemical pregnancy rate (14.41% vs. 11.3%, P = 0.386), clinical pregnancy rate (12.9% vs. 10.5%, P = 0.433), delivery rate (11.0% vs. 8.9%, P = 0.456), live birth rate (10.9% vs. 8.9%, P = 0.484) or pregnancy loss rate (14.6% vs. 15.4%, P = 1.000).ConclusionSperm DFI alone may have limited predictive power for IUI clinical outcomes.https://www.frontiersin.org/articles/10.3389/fendo.2022.987812/fullAIHIUIsperm DNA fragmentationSCSAROC curve |
| spellingShingle | Chunhui Zhu Chunhui Zhu Shengmin Zhang Fang Chen Hong She Yun Ju Xidong Wen Yurong Ji Yu Pan Chunxia Yang Yan Sun Naijun Dong Kaifeng Liu Feng Li Tongmin Xue Hengmi Cui Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI Frontiers in Endocrinology AIH IUI sperm DNA fragmentation SCSA ROC curve |
| title | Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI |
| title_full | Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI |
| title_fullStr | Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI |
| title_full_unstemmed | Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI |
| title_short | Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI |
| title_sort | correlations between elevated basal sperm dna fragmentation and the clinical outcomes in women undergoing iui |
| topic | AIH IUI sperm DNA fragmentation SCSA ROC curve |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.987812/full |
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