Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study
Abstract Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms by which physical activity alleviates MA use disorders are currently not fully understood. Based on this, the present study used untargeted me...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-05351-1 |
| _version_ | 1797557397887123456 |
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| author | Jisheng Xu Zhicheng Zhu Yu Jin Changling Wei Yi Wang Xue Li |
| author_facet | Jisheng Xu Zhicheng Zhu Yu Jin Changling Wei Yi Wang Xue Li |
| author_sort | Jisheng Xu |
| collection | DOAJ |
| description | Abstract Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms by which physical activity alleviates MA use disorders are currently not fully understood. Based on this, the present study used untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) to analyze the metabolic changes induced by MA in the brains of mice by exercise intervention. It was found that after 2 weeks of treadmill training, aerobic exercise modulated MA-induced brain metabolic disorders, in which 129 metabolites existed that were significantly differentiated in response to MA induction, and 32 metabolites were significantly affected by exercise. These differential metabolites were mainly enriched in glycerophospholipid metabolism, steroid hormone biosynthesis and degradation, and renin-angiotensin system pathways. To our knowledge, this study is the first to use LC-MS to investigate the effects of aerobic exercise on MA-induced brain metabolic profiling. The findings of this study provide new insights into exercise therapy using MA. |
| first_indexed | 2024-03-10T17:16:30Z |
| format | Article |
| id | doaj.art-a8c45269ce6143808ec831b8cbd0af15 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-10T17:16:30Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-a8c45269ce6143808ec831b8cbd0af152023-11-20T10:30:20ZengBMCBMC Psychiatry1471-244X2023-11-0123111510.1186/s12888-023-05351-1Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics studyJisheng Xu0Zhicheng Zhu1Yu Jin2Changling Wei3Yi Wang4Xue Li5School of Sports Medicine and Health, Chengdu Sport UniversitySchool of Sports Medicine and Health, Chengdu Sport UniversitySchool of Sports Medicine and Health, Chengdu Sport UniversitySchool of Sports Medicine and Health, Chengdu Sport UniversityDepartment of Epidemiology and Population Health, Albert Einstein College of MedicineSchool of Sports Medicine and Health, Chengdu Sport UniversityAbstract Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms by which physical activity alleviates MA use disorders are currently not fully understood. Based on this, the present study used untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) to analyze the metabolic changes induced by MA in the brains of mice by exercise intervention. It was found that after 2 weeks of treadmill training, aerobic exercise modulated MA-induced brain metabolic disorders, in which 129 metabolites existed that were significantly differentiated in response to MA induction, and 32 metabolites were significantly affected by exercise. These differential metabolites were mainly enriched in glycerophospholipid metabolism, steroid hormone biosynthesis and degradation, and renin-angiotensin system pathways. To our knowledge, this study is the first to use LC-MS to investigate the effects of aerobic exercise on MA-induced brain metabolic profiling. The findings of this study provide new insights into exercise therapy using MA.https://doi.org/10.1186/s12888-023-05351-1MethamphetamineAerobic exerciseMetabolomicsBrainSubstance abuse |
| spellingShingle | Jisheng Xu Zhicheng Zhu Yu Jin Changling Wei Yi Wang Xue Li Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study BMC Psychiatry Methamphetamine Aerobic exercise Metabolomics Brain Substance abuse |
| title | Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study |
| title_full | Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study |
| title_fullStr | Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study |
| title_full_unstemmed | Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study |
| title_short | Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study |
| title_sort | effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction lc ms based metabolomics study |
| topic | Methamphetamine Aerobic exercise Metabolomics Brain Substance abuse |
| url | https://doi.org/10.1186/s12888-023-05351-1 |
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